albendazole – methyl [5-(propilsulfanil)-1n-benzimidazole-2-il] carbamate belongs to the group of benzimidazole. Albendazole exhibits larvicidal, ovicidal and vermicidal activity, and is thought to exert its anthelmintic effect by inhibiting tubulin polymerization. This causes a cascade of metabolism disruption, including energy depletion, which immobilizes then kills the susceptible helminth.
Albendazole – broad-spectrum anthelmintics, effective on mature forms of trematodes (Fasciola hepatica and Dicrocоelium lanceatum), nematodes, that parasitize in the digestive tract and lungs (Bunostomum spp., Cooperia spp., Dictyocaulidae spp., Haemonchus spp., Nematodirus spp., Ostertagia spp., Strongyloides spp., Triсhostrongylus spp., Trichuris spp. etc.), and some species of cestodes (Avitellina centripumctata, Moniezia expansa, Moniezia benedeni, Thysaniezia giardi).
APPLICATION. Deworming of cattle, sheep, goats, horses, pigs, dogs, cats, furry animals, birds with nematodes lesions (mature and immature forms), some types of cestodes and trematodes.
Ivermectin has a pronounced antiparasitic effect on the larval and sexually mature stages of the nematodes of the gastrointestinal tract and lungs, larvae of subcutaneous, nasopharyngeal, gastric gadfly, lice, bloodsuckers, and sarcoptoid mites. The drug enhances the production of a neurotransmitter inhibition - gamma-aminobutyric acid, which leads to impaired transmission of nerve impulses, paralysis, and death of the parasite.
Due to the micellar dosage form of ivermectin and the addition of vitamin E, the drug is rapidly absorbed from the injection site, distributed in the organs and tissues of the animal, providing a parasiticidal effect for 10 to 14 days. In recommended doses, it does not have a sensitizing, embryotoxic, teratogenic and mutagenic effect. It is excreted mainly with urine and bile, in lactating animals with milk. In the external environment, the drug is rapidly destroyed. Toxic to fish and bees.
Levamisole hydrochloride, a left-turning isomer, belongs to the imidazole group and is a biologically active derivative of tetramisole. Inhibiting the enzyme acetylcholinesterase blocks the formation of ATP, affects the neuromuscular system of the parasite, causes contraction of its muscles and paralysis, which leads to the death of parasites in the first 12-24 hours after administration, In the liver of animals levamisole, is transformed into oxy-mercapto et imidazolidine, which has a positive effect on the immune system of mammals and birds.