Cyflodex eye and ear drops (Ciprofloxacin, Dexamethasone) 20 ml
Description:
Suspension is white.
Compound:
1 ml of the drug contains: ciprofloxacin hydrochloride – 4.5 mg, dexamethasone sodium phosphate – 1 mg.
Pharmacological properties:
A combined chemotherapeutic agent that combines a broad-spectrum antibiotic from the group of fluoroquinolones (ciprofloxacin) and GCS (dexamethasone), with antibacterial, anti-inflammatory, antiallergic and desensitizing properties.
Ciprofloxacin acts bactericidal by inhibiting DNA gyrase and suppressing bacterial DNA synthesis. Active against gram-negative microorganisms during dormancy and division – Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Vibrio spp., Campylobacter spp., Haidenia spp., Prov. stuartii, Haemophilus spp., Pasteurella multocida, Pseudomonas spp., Gardnerella spp., Neisseria spp., Moraxella catarrhalis, Acinetobacter spp., Brucella spp., gram-positive microorganisms during the division period – Staphylococcus spp. , Listeria monocytogenes and other pathogens – Chlamydia spp., Mycoplasma spp., Mycobacterium spp.
It is well absorbed, after 60 minutes its concentration in the lacrimal fluid is 4.98 μg / ml, and in the fluid of the anterior chamber of the eye – 2.59 μg / ml. The half-life from the anterior chamber of the eye is 2 hours. When instilled into the eyes, the concentration of ciprofloxacin in the blood does not exceed 2.5 ng / ml, when instilled into the ears, the maximum concentration in the blood is reached after 15-90 minutes and is approximately 0.1% of the concentration of ciprofloxacin administered orally at a dose of 250 mg.
Dexamethasone is a synthetic fluorinated GCS with anti-inflammatory, anti-allergic and antiproliferative effects. Reduces capillary permeability and proliferation, local exudation, cell infiltration, phagocytic activity, collagen deposition and fibroblast activity, suppresses the formation of scar tissue and symptoms of inflammation. The anti-inflammatory effect after instillation lasts 4-8 hours. When applied topically, systemic absorption is low. After instillation into the eyes, dexamethasone penetrates well into the corneal epithelium, conjunctival cells and into the fluid of the anterior chamber of the eye, its maximum concentration of 30 ng / ml is reached after 2 hours, the half-life is 3 hours. When applied to the ears, the maximum concentration in the blood is reached after 15-90 minutes and is approximately 14% of the concentration of dexamethasone,
Indications:
Treatment of dogs, cats, small, exotic and decorative animals with acute and chronic inflammation of the eyes and ears, which are the result of bacterial, chemical or traumatic effects – conjunctivitis, blepharitis, keratitis, keratoconjunctivitis, iriditis, iridocyclitis, corneal ulcers and erosion, eye diseases after injuries or the ingress of foreign bodies or aggressive compounds in the post and preoperative periods, as well as otitis media, otorrhea, in particular, caused by outside interference.
Contraindications:
Do not administer to animals with hypersensitivity to the active ingredients of the drug.
Method of administration and dosage:
The drug is instilled into the conjunctival sac 1-2 drops 2-4 times a day (in difficult cases 1-2 drops are instilled every 2-3 hours for 1-2 days) or the ear canal 1-4 drops (depending on the weight animal) 2-3 times a day.
In the presence of significant purulent or mucopurulent discharge, preliminary hygienic treatment of the eyes or ears is carried out: 3-4 drops are instilled and the discharge is removed with a sterile gauze swab, after which 1-2 drops of the drug are instilled. The course of treatment until complete recovery is 5-10 days.
Caution:
When instilled into the eyes, local irritation, itching, lacrimation are sometimes possible, which quickly pass, occasionally – allergic reactions, and with prolonged use – the development of secondary glaucoma, steroid cataracts. Apply carefully to animals for up to 7 days.
Package :
10 ml polymer vials with a dropper in an individual cardboard box.
Storage conditions:
Store in a dry, dark place, out of the reach of children, at temperatures from +10 to + 25 ° С.
After opening the bottle, use the drug within 30 days.
Expiration date: 2 years.