Milprazon (milbemycin oxime, praziquantel) wormer for dogs over 5 kg, 12.5 mg/125 mg, 2 tablets
Description
Oval tablets are biconvex yellowish-white with brown spots with a line on one side.
Storage
1 tablet contains active substances:
- milbemycin oxime – 12.5 mg
- praziquantel – 125 mg.
Excipients: microcrystalline cellulose, lactose monohydrate, povidone, croscarmellose sodium, colloidal anhydrous silicon, magnesium stearate, meat flavoring, yeast powder.
Pharmacological properties
ATCvet QP54, (QP54AB51,)
Pharmacodynamics
Milprazone is a combined anthelmintic drug with nematicidal and cestocidal action. The active substances that are part of the drug, cause its wide range of anthelmintic action.
Milbemycin oxime is a macrocyclic lactone obtained by fermentation of Streptomyces hygroscopicus, type Aureolacrimosus, active against larvae and adult nematodes that parasitize in the digestive tract of dogs, as well as against larvae of nematodes Dirofilaria immitis (microdirophylaria). The mechanism of action of milbemycin is due to increased permeability of cell membranes for chlorine ions (Cl-), which leads to polarization of cell membranes of nerve and muscle tissue, paralysis and death of the parasite.
Praziquantel is a derivative of acylated pyrazinisoquinoline. Praziquantel is active against cestodes and trematodes. By increasing the permeability of the parasite’s cell membranes to calcium ions (Ca2 +), it causes depolarization of the membranes, muscle contraction and destruction of the tegument, which leads to the death of the parasite and promotes its excretion from animals.
Pharmacokinetics
After oral administration of the drug, the maximum concentration of milbemycin oxime in the blood plasma of dogs is reached within 2-4 hours, the bioavailability is about 80%. It is excreted from the body of animals, mostly unchanged. Praziquantel, after oral administration in dogs, after a small portion of food, quickly reaches the peak level of the starting material in plasma (Tmax approximately 0.25-2.5 hours) and decreases rapidly (t1 / 2 approximately 1 hour); the compound is rapidly and almost completely biotransformed in the liver, the level of binding in plasma is about 80%, excreted in the urine within 2 days.
In rats, metabolism is complete but slow because milbemycin oxime has not been detected unchanged in urine or faeces. The main metabolites in rats are monohydroxylated derivatives associated with hepatic biotransformation. In addition to relatively high concentrations in the liver, there is some level of concentration in adipose tissue, which indicates the lipophilicity of the substance.
Milprazone by the degree of action on the body belongs to the low-toxic substances (safety class 4), in the recommended doses does not show sensitizing, embryotoxic and teratogenic effects, well tolerated by dogs of different breeds and ages. The drug is toxic to bees, as well as fish and other aquatic organisms.
Application
Prevention and treatment of dogs in invasions caused by cestodes – Dipylidium caninum, Taenia spp., Echinococcus spp., Mesocestoides spp .; nematodes – Ancylostoma caninum, Toxocara canis, Toxascaris leonina, Trichuris vulpis, Thelazia callipaeda; Angiostrongylus vasorum (reduces the intensity of infection), Crenosoma vulpis (reduces the intensity of infection), Dirofilaria immitis (disease prevention); incl. with combined nematode-cestode invasions.
The drug can also be used to prevent heartworm disease (Dirofilaria immitis), if concomitant treatment against cestodes is indicated.
Dosage
The drug is used in dogs once during feeding with a small amount of food or forcibly injected into the root of the tongue after feeding in the minimum therapeutic dose: 0.5 mg of milbemycin oxime and 5 mg of praziquantel per kg of body weight.
Depending on the weight of the dog, the actual dosage is:
Body weight | Number of tablets |
5 – 25 kg | 1 tablet |
> 25 – 50 kg | 2 tablets |
> 50 – 75 kg | 3 tablets |
Pre-starvation diet and the use of laxatives before deworming is not required.
For deworming of dogs in the invasion caused by Angiostrongylus vasorum, the drug Milprazon is used for therapeutic purposes four times with an interval of 7 days; for prophylactic purposes – every 4 weeks in a therapeutic dose. If concomitant treatment with cestodes is indicated, the drug can be replaced with a monovalent agent containing only milbemycin oxime.
For deworming of dogs in the invasion caused by Thelazia callipaeda, the drug is used twice with an interval of 7 days. If concomitant treatment with cestodes is indicated, the drug can be replaced with a monovalent agent containing only milbemycin oxime.
In order to prevent heartworm disease in unfavorable regions, the drug is used in the spring-summer-autumn period: before the flight of mosquitoes and gnats (intermediate hosts of D. immitis) once, then once a month and last time in season one month after the flight of insects . Prior to deworming, consult a veterinarian to rule out the presence of microdirofilariae in the animal’s blood.
Features of action of drug at its first application and cancellation aren’t established.
When carrying out deworming it is necessary to adhere to the recommended terms. In case of skipping the next treatment, the drug is resumed in the same dose and according to the same scheme.
Contraindication
Increased individual sensitivity of animals to the components of the drug (including in the anamnesis)!
Severe renal and hepatic dysfunction!
Do not use the drug on animals weighing less than 5 kg!
Do not use in depleted and infectious animals!
Reservation
Deworming of animals during pregnancy and lactation is carried out if necessary under the supervision of a veterinarian.
When using the drug strictly adhere to the recommended dosage.
Collie, Bobtail and Sheltie dogs are sensitive to all anthelmintic drugs, so Milprazon should be used as needed and under the supervision of a veterinarian. Tolerability of the drug in young puppies of this breed has not been studied.
Treatment of dogs with high levels of circulating Dirofilaria immitis can lead to side effects (pale mucous membranes, vomiting, muscle tremors, difficulty breathing or hypersalivation). These reactions are associated with the release of proteins from dead microfilariae and do not indicate direct toxicity of the drug. Treatment of canine microfilaraemia (presence of larvae in the blood) with Milprazone is not recommended.
In areas at risk of heartworm disease or in cases where the dog is imported or removed from the risk area, it is necessary to consult a veterinarian before using the drug to rule out the disease. In the case of diagnosing heartworm disease (Dirofilaria immitis) before using the drug, the animal is recommended to first use drugs against adult helminths.
Weakened and sick animals use the drug only under the supervision of a veterinarian with a benefit / risk assessment.
For dogs under 4 weeks of age, trematode lesions are atypical, so the use of the combined drug Milprazon is inappropriate.
Release form
Blisters of foil OPA / Al / PVC cold stamping and aluminum foil 2 and 4 tablets. Blisters are packed in boxes.
- Box of 1 blister of 2 tablets.
- Box of 1 blister of 4 tablets.
- Box of 12 blisters of 4 tablets.
Storage
The drug is stored in the original packaging of the manufacturer, separately from food and feed, in a dry place, protected from direct sunlight, out of reach of children and animals at a temperature of 5 to 25 ° C. The halved tablets should be stored below 25 ° C in the original blister. Store the blister in the outer carton.
Expiration date
3 years. The shelf life of the bisected tablets after opening the original package is 6 months.
For use in veterinary medicine!