DESCRIPTION. Oily suspension of white color with a specific smell.
PHARMACOLOGICAL CHARACTERISTICS. Procaine penicillin is a bactericidal antibiotic of penicillin group, that acts on gram-positive and gram-negative bacteria: Campylobacter spp., Clostridium spp., Corynebacterium spp., Erysipelothrix spp., Actinobacillus spp., Haemophilus spp., Listeria spp., Pasteurella spp., Staphylococcus spp., Streptococcus spp. Its mechanism of action provides violation of peptidoglycan synthesis – mucopeptide of cell membrane that leads to inhibition of microorganism cell wall synthesis, inhibition of bacteria growth.
Streptomycin sulfate belongs to a subgroup of streptomycin and to a group of natural aminoglycosides and is an antibiotic with bactericidal antimicrobial action type. The substance acts on bacteria that are in the stage of reproduction and somewhat weaker on microbes in the resting stage. Bactericidal action of antibiotic is realized by inhibiting of protein synthesis of microbial cells. Streptomycin sulfate has antimicrobial activity against many gram-positive and gram-negative bacteria, including acid and penicillin-resistant forms, inhibiting the growth of most bacteria, which belong to the genus Staphylococcus, Streptococcus, Brucella, Klebsiella, Mycobacterium, Neiseria, Pasteurella, Salmonella, Shigella, Haemophilus, etc.
In center of an inflammation under the influence of streptomycin is reduced edema and infiltration, is accelerated the transition of exudative reaction to productive.
Neomycin sulfate belongs to a neomycin subgroup and to a group of natural aminoglycosides formed by actinomycetes.
Neomycin – antibiotic with a broad spectrum of antimicrobial activity. It is active against many gram-negative bacteria and cocci (E.coli, genera Salmonella, Shigella, Meningococcus), and gram-positive bacteria (Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysgalactiae, Enterococcus spp.). Bactericidal action of antibiotic, as well as other members of the aminoglycosides group is realized by inhibiting of protein synthesis of microbial cells.
Prednisolone is a dehydrated analogue of hydrocortisone. It has properties inherent to other compounds of this group, namely: has anti-inflammatory, anti-allergic and desensitizing effect, antishock and antitoxic properties. Stimulating steroid receptors, it induces the formation of a special class of proteins – lipocortins that have anti-edema activity and also reduces the activity of hyaluronidase and reduces the permeability of capillaries.
APPLICATION. Treatment of cows various forms of mastitis of bacterial etiology during lactation.
DOSAGE. The contents of one syringe tube inject into share of the affected breast, which previously milk and disinfect. After the injection quarter of breast massage for uniform distribution throughout the tank. Repeated application is carried out every 24 hours for 3 days.
CONTRAINDICATIONS. Do not use the drug to animals susceptible to penicillin and aminoglycoside group.
PRECAUTIONS. Slaughter of animals for meat is permitted in 7 days after the last injection. The use of milk in food by people is allowed in 108 hours after the last drug application. Obtained by the deadline meat and milk fed to unproductive animals or utilize (depending on a conclusion of doctor of veterinary medicine).
STORAGE. Dry, dark, inaccessible to children at temperature from 15°C to 25°C.
Expiration date – 2 years from date of manufacture.
Syringes intramammary (syringe tubes) 5 g, packed in a polymeric package.
1 syringe tube (5 g) contains active substances:
procaine penicillin – 100 000 IU;
streptomycin sulfate – 100 mg;
neomycin sulfate – 100 mg;
prednisolone – 10 mg;
Excipients – up to 5 g.
Antimastitis agents 256