Zinaprim, 1 kg (sulfamethazine, trimethoprim), 1000 g

Fine white-yellow powder.

Compound

1 g of the drug contains active ingredients:

• sulfamethazine – 200 mg,
• trimethoprim – 40 mg.

Excipients: silicone dioxide, dextrose, lactose.

Pharmacological properties

ATCvet classification code QJ01 – antibacterial veterinary drugs for systemic use. QJ01EW30 – combinations of sulfonamides and trimethoprim.

Zinaprim is a combined chemotherapeutic drug with a broad spectrum of antimicrobial action.

Sulfamethazine is a synthetic chemotherapeutic agent from the sulfonamide group. Trimethoprim is a synthetic chemotherapeutic agent derived from diaminopyrimidine.

Separately, each component has a mechanism of action similar to bacteriostatic, but sulfamethazine and trimethoprim, taken in a 5: 1 ratio, enhance the antimicrobial activity of the drug and give it a bactericidal nature of action.

This synergism of the association is manifested due to the fact that its components affect two sequential processes that are necessary for the synthesis of tetrahydrofolic acid or bacterial folic acid, which plays a major role in the synthesis of bacterial purines. The action of these two components is as follows:

• sulfamethazine in its chemical characteristics is similar to p-aminobenzoic acid, and together with it participates in the formation of the enzyme dihydropteroyl synthetase, counteracting the formation of dihydrofolic acid;
• trimethoprim blocks the next link in the biosynthetic chain, inhibiting the action of dihydrofolate reductase, an enzyme that accelerates the conversion of dihydrofolic acid to tetrahydrofolic acid.

The combination of these chemotherapeutic components endows the drug with bactericidal action. At the same time, the appearance of strains of microorganisms resistant to the action of the drug is insignificant.

The combination sulfamethazine-trimethoprim has a broad spectrum of action, including gram-positive and gram-negative bacteria. Microorganisms that are very sensitive to the action of the drug include the following bacteria: Escherichia coli, Clostridium spp., Shigella spp., Salmonella spp., Proteus mirabilis, Bacillus anthracis, Pasteurella spp., Haemophilus influenzae, Haemophilus gallinarum and Vibrio spp. Streptococcus pneumoniae, S. pyogenes, S. faecalis, S. viridans, S. agalactiae, Staphylococcus aureus, Proteus spp. and Brucella spp.

Both components of the drug are completely absorbed from the digestive tract. The maximum concentration of the active components of the drug in the blood serum is observed after 1 to 4 hours.

Trimethoprim penetrates cells and tissue barriers – lungs, kidneys, prostate, bile, saliva, phlegm, cerebrospinal fluid. The binding of trimethoprim to proteins is 50%, the half-life is normal from 8.0 to 17 hours. The main route of excretion of trimethoprim is through the kidneys, 50% – unchanged.

The binding of sulfamethazine to plasma proteins is 66%, the half-life is normal from 9 to 11 hours. The main route of excretion is through the kidneys, moreover, from 15 to 30% in the active form.

Application

Calves under the age of 3 months: treatment of animals suffering from colibacillosis and salmonella gastroenteritis, vibriosis, pneumonia, pasteurellosis, mastitis, actinomycosis, as well as diseases of the genitourinary system caused by microorganisms sensitive to sulfamethazine and trimethoprim.

Horses: treatment of animals suffering from diarrhea, pneumonia, mumps, pyosepticemia caused by microorganisms sensitive to sulfamethazine and trimethoprim.

Pigs: treatment of animals suffering from colibacillosis, salmonellosis, vibrious dysentery, pneumonia, pasteurellosis, malignant edema, abscesses caused by microorganisms sensitive to sulfamethazine and trimethoprim.

Poultry (chickens, broilers, replacement poultry): treatment of poultry sick with salmonellosis, colibacillosis, streptococcal infections, pasteurellosis, with bacterial complications after viral infections caused by microorganisms sensitive to sulfamethazine and trimethoprim.

Dogs and cats: treatment of animals with septicemia, bacterial enteritis, and respiratory diseases caused by microorganisms sensitive to sulfamethazine and trimethoprim.

Dosage

Orally with drinking water, milk or feed in doses:

• Calves (up to 3 months), pigs, horses, dogs and cats – 1 g of the drug per 10 kg of body weight daily for 3-5 days. The first day of treatment: it is recommended to use the drug twice a day in fixed doses.
• Poultry (chickens, broilers, replacement poultry): the first day – 1 g of the drug per 1 liter of drinking water daily; 2-3 next days – 0.5 g of the drug per 1 liter of drinking water daily.

Contraindications

Do not use in animals with individual hypersensitivity to sulfamethazine and trimethoprim.

Do not administer to animals with renal and hepatic insufficiency. Do not use simultaneously with p-aminobenzoic acid and folates.

Do not use in ruminants with functionally developed proventriculus.

Do not use in laying hens whose eggs are used for human food.

Side effect

In therapeutic doses, side effects are practically not observed. Side effects, which are usually observed with prolonged use, can lead to digestive disorders such as nausea, vomiting, diarrhea.

Application during pregnancy, lactation, egg production

The drug is not recommended for use during pregnancy.

Withdrawal period (withdrawal)

Slaughter of animals and poultry for meat is allowed 5 days after the last use of the drug. The meat obtained before the specified period is disposed of or fed to unproductive animals, depending on the conclusion of a veterinary doctor.

Release form

The container, with a capacity of 1 kg, is a hermetically sealed aluminum package with an inner polyethylene lining.

Storage

A dry, dark place, out of the reach of children, at a temperature of 5 ° C to 25 ° C.

Expiration date – 5 years from the date of manufacture.

After dissolving the drug in water, the shelf life of the solution is 24 hours.

For use in veterinary medicine!