Zinaprim (sulfamethazine, trimethoprim) Solution 100 ml

The solution is yellowish.

Compound

1 ml of the preparation contains active ingredients:

• sulfamethazine – 200 mg
• trimethoprim – 40 mg.

Excipients: citric acid, sodium pyrosulfite, hydrochloric acid, sodium hydroxide, sodium methyl p-hydroxybenzonate, sodium propyl p-hydroxybenzonate, water for injection.

Pharmacological properties

Sulfamethazine is a synthetic chemotherapeutic agent from the sulfamide group. Trimethoprim is a synthetic chemotherapeutic agent derived from diaminopyrimidine.

Separately, each component has a bacteriostatic mechanism, but sulfamethazine and trimethoprim, taken in a 4: 1 ratio, enhance the effect of the drug and give it a bactericidal nature of action.

Such synergism is manifested due to the fact that its components affect two sequential processes that are necessary for the synthesis of tetrahydrofolic acid or bacterial folic acid, which plays a major role in the synthesis of bacterial purines. The bacterial wall is impermeable to folates, so the synthesis of purines depends on the intrinsic synthesizing ability of microorganisms.

The action of these two components is as follows:

• sulfamethazine, in its chemical characteristics, is similar to p-aminobenzoic acid, and together with it participates in the formation of the enzyme dihydropteroyl synthetase, counteracting the formation of dihydrofolic acid;
• trimethoprim blocks the next link in the biosynthetic chain, inhibiting the action of dihydrofolate reductase, an enzyme that accelerates the conversion of dihydrofolic acid to tetrahydrofolic acid.

The combination of these chemotherapeutic components endows the drug with a bactericidal effect. At the same time, the appearance of microbial strains resistant to the action of the drug is insignificant.

The combination sulfamethazine-trimethoprim has a broad spectrum of action, including gram-positive and gram-negative bacteria. Microorganisms that are very sensitive to the action of the drug include the following bacteria: Escherichia coli, Clostridium spp., Shigella spp., Salmonella spp., Proteus mirabilis, Bacillus anthracis, Pasteurella spp., Haemophilus influenzae, Haemophilus gallinarum and Vibrio spp. Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus viridans, Streptococcus agalactiae, Staphylococcus aureus, Proteus spp. and Brucella spp.

Application

Cattle: treatment of animals suffering from colibacillosis and salmonella gastroenteritis, vibriosis, pneumonia, septicemia, pasteurellosis, coccidiosis and colibacillosis mastitis, actinomycosis, purulent abscess, as well as diseases of the genitourinary system caused by sulphamethyroidism and sulfimetasis-sensitive microorganisms.

Horses: treatment of animals suffering from diarrhea, pneumonia, pyosepticemia caused by microorganisms sensitive to sulfametazim and trimethoprim.

Pigs: treatment of animals suffering from colibacillosis, salmonellosis, vibrious dysentery, pneumonia, pasteurellosis, malignant edema, abscesses caused by microorganisms sensitive to sulfametazim and trimethoprim.

Sheep: treatment of animals suffering from colibacillosis, salmonellosis, vibrious dysentery, pneumonia, enteritis, abscesses and mastitis caused by microorganisms sensitive to sulfametazim and trimethoprim.

Dogs, cats: treatment of animals with pulmonary infections, septicemia, bacterial enteritis, coccidiosis in dogs caused by microorganisms sensitive to sulfametazim and trimethoprim.

Dosage

Intramuscularly at a dose of 1 ml per 10 kg of animal body weight daily for 3-5 days. The first day of treatment, the daily dose is divided into two parts and administered at intervals of 12 hours.

Contraindications

Hypersensitivity to sulfonamides. Do not administer to animals with renal or hepatic impairment. Do not use in conjunction with folates and p-aminobenzoic drugs.

Warning

Slaughter of animals for meat is allowed 28 days after the last use of the drug. The consumption of milk for human consumption is allowed 4 days after the last use of the drug. The meat and milk received before the specified time is disposed of or fed to unproductive animals, depending on the conclusion of the veterinary doctor.

Release form

Bottles made of transparent brown hydrolytic glass, closed with a rubber stopper for aluminum rinsing, 100 ml each. Secondary packaging – cardboard box.

Storage

A dry, dark place, out of the reach of children, at a temperature of 5 ° to 25 ° C.

The shelf life is 5 years.

For use in veterinary medicine!