Advantix drops for fleas and ticks for dogs weighing up to 4 kg, 0.4 ml, 4 pipettes

Composition and form of release

Combined insect-acaricidal preparation containing as active ingredients 10% imidacloprid {1- (6-chloro-3-pyredylmethyl) -N-nitro-imidazolidine-2} and 50% permethrin {3-phenoxybenzyl-2,2-dimethyl- 3- (2,2-dichloro-vinyl) -cyclopropane carboxylate}, as well as auxiliary components. It is a clear liquid from yellow to brown in color with a weak specific odor. The drug is produced in 0.4 ml packs in polyethylene pipette tubes, packed in blisters of 4 pieces.

Pharmacological properties

Imidacloprid and permethrin, which are part of Advantix, exhibiting synergistic action, have a systemic, contact and repellent effect on insects and ixodid ticks parasitizing dogs. The drug is effective against the imaginal and preimaginal phases of development of lice, fleas, lice and ixodid ticks, protects animals from the attack of mosquitoes, midges and mosquitoes. The mechanism of action of the synthetic pyrethroid permethrin is to block the transmission of nerve impulses, which causes impaired coordination of movements, paralysis and death of ectoparasites. Imidacloprid belongs to the group of chloronicotinyl insecticides, the mechanism of action of which is based on interaction with arthropod acetylcholine receptors and impaired transmission of nerve impulses. Acting as an activator of the arthropod ganglion, imidacloprid enhances the insect-acaricidal effect of permethrin. After the application of Advantix, its active components, practically not absorbed into the systemic circulation, are quickly distributed over the surface of the body and are retained on the epidermis and wool, have a long-term contact insect-acaricidal and repellent effect. According to the degree of toxic effect on the body, Advantix belongs to moderately hazardous substances, in the recommended doses it does not have a resorptive-toxic, embryotoxic, teratogenic, mutagenic and sensitizing effect, when it gets into the eyes it causes slight irritation. The drug is toxic to cats, bees, as well as fish and other aquatic organisms. quickly spread over the surface of the body and are retained on the epidermis and wool, have a long-term contact insect-acaricidal and repellent effect. According to the degree of toxic effect on the body, Advantix belongs to moderately hazardous substances, in the recommended doses it does not have a resorptive-toxic, embryotoxic, teratogenic, mutagenic and sensitizing effect, when it gets into the eyes it causes slight irritation. The drug is toxic to cats, bees, as well as fish and other aquatic organisms. quickly spread over the surface of the body and are retained on the epidermis and wool, have a long-term contact insect-acaricidal and repellent effect. According to the degree of toxic effect on the body, Advantix belongs to moderately hazardous substances, in the recommended doses it does not have a resorptive-toxic, embryotoxic, teratogenic, mutagenic and sensitizing effect, when it gets into the eyes it causes slight irritation. The drug is toxic to cats, bees, as well as fish and other aquatic organisms. mutagenic and sensitizing action, causes slight irritation in contact with eyes. The drug is toxic to cats, bees, as well as fish and other aquatic organisms. mutagenic and sensitizing action, causes slight irritation in contact with eyes. The drug is toxic to cats, bees, as well as fish and other aquatic organisms.

Indications

For the destruction of insects and ixodid ticks parasitizing on dogs, as well as protecting animals from their attack.

Doses and method of administration

The drug is applied by topical (drip) application of the drug to dry, intact skin. Before use, pierce the protective membrane of the nozzle of the pipette tube (putting on the cap on the back side), pushing the fur apart and pressing the pipette tube, apply the drug to the skin in a place inaccessible for licking by the animal (between the shoulder blades). When processing large dogs, the contents of the pipette tube are applied to the skin in three to four places on the back from the shoulder blades to the sacrum. The death of insects parasitizing on the animal occurs within 12 hours, the death or detachment of ixodid ticks – within 48 hours after treatment. The repellent effect of the drug against lice, fleas, lice, dipterans, blood-sucking insects, as well as ixodid ticks after a single treatment of the animal lasts 4-6 weeks. Repeated processing of animals is carried out according to indications, but not more often than once a month. In the treatment of allergic dermatitis caused by insects, it is advisable to use the drug in combination with drugs for pathogenetic and symptomatic therapy.

Side effects

In rare cases, after using the drug, individual skin reactions (redness, itching) are possible, which spontaneously disappear within 1-4 days and do not require the use of drugs.

Contraindications

It is forbidden to use Advantix for cats. It is not allowed for use by patients with infectious diseases and recovering dogs, puppies under 7 weeks of age and / or weighing less than 1.5 kg, as well as animals of other species. Use with caution in pregnant and lactating bitches. The simultaneous use of Advantix with other insect-acaricidal drugs is not allowed.

special instructions

In view of the possible contamination of tissues, plastic and other materials by the preparation, contact of the treated animal with the surrounding objects should not be allowed until the preparation is completely dry at the processing site. During processing, the animal is not allowed to smoke, drink or eat. At the end of the procedure, you should thoroughly wash your hands with warm water and soap. Advantix is ​​not recommended to be applied to damp or damaged skin, to wash the animal within 7 days after treatment with the drug. Do not wash, iron and let the animal near small children within 24 hours after treatment with the drug. In case of accidental contact of the drug on the skin or eyes, it should be washed off immediately with a stream of water, if ingested – consult a doctor.

Storage conditions

Store in a dry, dark place, out of reach of children and animals, separately from food and feed at temperatures from 0 to 25 ° C.

Shelf life – 3 years, after opening the blister – no more than 1 year