Roncoleikin 2 000 000 ME 10ml immunomodulator

Composition and form of release
Immunomodulator Roncoleukin is a dosage form of recombinant human interleukin-2 (rIL-2), isolated and purified from yeast cells Saccharomyces cerevisiae, sodium dodecyl sulfate (SDS) solubilizer, D-mannitol stabilizer and dithiothreitol reductant … In appearance, the drug is a transparent opalescent liquid. Roncoleukin for injection is packaged in doses: 0.5 cm 3  (500,000 IU), 0.25 cm 3  (250,000 IU), 0.1 cm 3  (100,000 IU), 0.05 cm 3  mg (50,000 IU ) – in ampoules.

Pharmacological properties
Interleukin-2 is produced by a subpopulation of T-lymphocytes (T-helper cells I) in response to antigenic stimulation. The synthesized IL-2 acts on T-lymphocytes, enhancing their proliferation and the subsequent synthesis of IL-2. The biological effects of IL-2 are mediated by its binding to specific receptors on various cellular targets. IL-2 has a directed effect on the growth, differentiation and activation of T- and B-lymphocytes, monocytes, macrophages, oligodendroglial cells, Langerhans epidermal cells, increases the synthesis of all immunoglobulin isotypes by plasma cells. IL-2 reduces the level of spontaneous apoptosis of helper T-lymphocytes, increases the production of interferons α, β, γ. The development of cytolytic activity of natural killer cells and cytotoxic T-lymphocytes depends on its presence. IL-2 induces the formation of lymphokine-activated killers and activates tumor-infiltrating cells. Expansion of the spectrum of the lyzing action of effector cells causes the elimination of various pathogenic microorganisms, infected and malignant cells, which provides immune protection against the growth of tumor cells, as well as viral, bacterial and fungal infections.

Doses and method of administration
Subcutaneously (s / c): dissolve the contents of the ampoule in 2-5 ml of 0.9% sodium chloride solution or water for injection.

Intravenous (IV): Transfer the contents of the ampoule with Roncoleukin into 100-400 ml of 0.9% sodium chloride for injection.

Intranasally: dissolve the contents of the ampoule in 4 ml of 0.9% sodium chloride solution or water for injection.

Instill into the nose at the rate: for animals weighing up to five kilograms, use an ampoule of 100,000 IU, for animals weighing up to 20 kilograms, use an ampoule of 250,000 IU, for animals weighing over 20 kilograms, use an ampoule of 500,000 IU. Instill two drops in each nostril at least 3-5 times a day.

Outwardly: dissolve the contents of the ampoule in 5-10 ml of 0.9% sodium chloride solution or water for injection and use in the form of applications or surface irrigation.

Intercisstial (intravesical): dissolve the contents of the ampoule 100,000 – 250,000 IU in 5-50 ml (depending on the size of the animal) 0.9% sodium chloride solution and inject through the catheter.

Orally: dissolve the contents of the ampoule in 2-10 ml of 0.9% sodium chloride solution or water for injection (depending on the size of the animal) and feed the animal.

Aerosol: dilute the contents of the ampoule in the required amount with 0.9% sodium chloride solution or water for injection and spray on the installation or directly into the animal’s oral cavity.

When diluting Roncoleukin, do not shake the ampoule vigorously to avoid foaming. The drug can be prescribed for therapeutic and prophylactic purposes, starting from a newborn age.

Horses:
The drug is administered intravenously or subcutaneously at intervals of 24-72 hours. The average course of treatment is 2-3 injections, and the maximum is 5 injections. In chronic bronchial obstruction, the drug is administered only after the relief of acute bronchial hyperreactivity syndrome. For the prevention of transport dysregulation, Roncoleukin is recommended to be administered 24 hours before loading the horse, subcutaneously, once at a dose of 1000 IU / kg of body weight. In case of alveolar pulmonary emphysema, the drug is administered to horses once a month, once subcutaneously or intravenously, 2000 IU / kg, and in order to prevent asthmatic attacks in horses with chronic bronchial obstruction. Roncoleukin is administered monthly at the same dosage subcutaneously twice with an interval of 48 hours. During the competitive period and the period of greatest physical exertion, Roncoleukin is administered to increase the reserve capabilities of the body on the day of rest – once a week, subcutaneously, once in a dose of 1000 IU / kg of body weight. Roncoleukin is recommended to be administered for the purpose of immunorehabilitation after the use of corticosteroids and a course of other immunosuppressants – 1000 IU / kg 2-3 injections with an interval of 48-72 hours. Roncoleukin is a universal means of maintaining the life of old and weakened animals – intravenously or subcutaneously at a dose of 1000 IU / kg of body weight, 2-3 injections monthly.

Cattle:
For medicinal purposes, the drug is administered intravenously or subcutaneously at the rate of 1000 IU / kg of body weight. The drug is administered 1-3 times, with an interval of 4-7 days. Calves – at the rate of 2000-3000 IU / kg with an interval of 72 hours 2-3 injections. For the prevention of viral, bacterial and fungal diseases, the drug is administered subcutaneously at the rate of 1000 IU / kg of body weight, 1-2 injections with an interval of 48 hours. Prevention is carried out 2 times a year with an interval of 6 months. Roncoleukin is also used as a means of relieving stress during various manipulations, transportation, appraisal at a dose of 1000 IU / kg once, but no later than 48 hours before the start of the proposed actions.

For infectious diseases of bacterial, fungal or viral etiology:
acute form of the disease – it is recommended to use the drug at a dose of 1000 IU / kg, the interval between injections is from 2 to 7 days. In the complex therapy of infectious diseases, 2-3 injections of Roncoleukin are used, in the treatment of severe forms – up to 5 injections. In the case of necrobacteriosis treatment, Roncoleukin can be used as monotherapy. The interval between injections is 7-10 days.

To stimulate hunting, it is used in a dosage of 1000 IU / kg twice with an interval of 24-48 hours. As a result, hunting occurs without the use of hormonal stimulants, the normalization of heat and ovulation occurs 60% faster compared to standard treatment methods. It is recommended to administer for the purpose of immunorehabilitation after cases of using corticosteroids and a course of other immunosuppressants 1-2 injections with an interval of 48-72 hours at the indicated dose. Roncoleukin is also used as a vaccine adjuvant. A single dose of 1000 IU / kg is recommended. To stimulate innate immunity in calves on the first day of birth, a single subcutaneous injection is recommended at a dose of 100,000 IU.

Small ruminants:
The drug is administered intravenously or subcutaneously at the rate of 2000 IU / kg with an interval of 24-72 hours 2-3 injections. For young animals, the dose may be increased up to 5000 IU / kg. For the prevention of viral, bacterial and fungal diseases, the drug is administered subcutaneously at the rate of 2000 IU / kg of body weight, 1-2 injections with an interval of 48 hours. Prophylaxis is carried out 2 times a year with an interval of 6 months.

Pigs:
The drug is administered intravenously or subcutaneously at the rate of 2000 IU / kg with an interval of 24-72 hours, 1-3 injections. Piglets may increase the dose up to 5000 IU / kg. For the prevention of viral, bacterial and fungal diseases, the drug is administered subcutaneously at the rate of 2000 IU / kg of body weight, 1-2 injections with an interval of 48 hours. Prophylaxis is carried out 2 times a year with an interval of 6 months. It is possible to use aerosol or in the form of a drink at the rate of 2000-5000 IU / kg with an interval of 24-72 hours, for piglets it is possible to increase the dose to 5000 IU / kg. In some cases, it is possible to administer the drug in the form of a circular (short) blockade, external applications. In acute injuries, in order to prevent purulent complications, it is administered subcutaneously once at a dose of 2000-3000 IU / kg. Roncoleukin is recommended to be administered for the purpose of immunorehabilitation after the use of corticosteroids and a course of other immunosuppressants 1-2 injections with an interval of 24-48 hours at the indicated dose. It is also used as a means of relieving stress during various manipulations, transportation, weaning, but no later than 48 hours before the start of the proposed action at a dose of 2000 IU / kg once. Roncoleukin is also used as an adjuvant for vaccines at a dose of 2000 IU / kg once. To stimulate the innate immunity of piglets on the first day of birth, subcutaneous administration is recommended at a dose of 5000 IU / kg once. than 48 hours before the start of the intended action at a dose of 2000 IU / kg once. Roncoleukin is also used as an adjuvant for vaccines at a dose of 2000 IU / kg once. To stimulate the innate immunity of piglets on the first day of birth, subcutaneous administration at a dose of 5000 IU / kg once is recommended. than 48 hours before the start of the intended action at a dose of 2000 IU / kg once. Roncoleukin is also used as an adjuvant for vaccines at a dose of 2000 IU / kg once. To stimulate the innate immunity of piglets on the first day of birth, subcutaneous administration is recommended at a dose of 5000 IU / kg once.

Agricultural poultry:
The drug is used as a vaccine adjuvant once subcutaneously or orally (in the form of a drink) simultaneously with vaccination at the rate of 2000 IU / kg. For subcutaneous administration, administration in the same syringe with the vaccine is allowed. You can also use aerosol at the rate of 1000-3000 IU / kg once. As a result, the body’s immune response increases, the likelihood of successful vaccination increases, the safety of young animals increases, and the body weight of the bird increases. To stimulate innate immunity, the drug is used in the first day of a bird’s life. The natural resistance of the organism increases, the content of lysozyme in the tracheobronchial secretion increases, the content of vitamin A in the liver of chickens increases, the safety of young animals increases, the content of erythrocytes, leukocytes, total protein and hemoglobin increases.

The use of the drug for broiler chickens can significantly reduce the cost of medical preparations, it becomes possible to obtain a livestock of poultry raised without antibiotics, and also to reduce the consumption of feed per planted head.

Pets and fur animals:
The drug is administered intravenously or subcutaneously at intervals of 24-48 hours. The average course of treatment is 2-3 injections at the rate of 10,000 IU / kg. In the case of treatment of oncological diseases, 5 injections at the rate of 15,000 IU / kg, after a month it is necessary to repeat the course, use in conjunction with surgery to prevent metastasis and the occurrence of secondary immunodeficiencies, leading to the occurrence of postoperative complications. Roncoleukin must also be used during or after chemotherapy and radiation therapy. The drug is administered intravenously or subcutaneously at the rate of 10,000-15,000 IU / kg once a day. The course of treatment is up to 5 injections with an interval of 24-48 hours. After 30 days, it is recommended to repeat the course. When using Roncoleukin as an adjuvant of vaccines and as a stress reliever during various manipulations, transportation, it is recommended to use a dose of 5000 IU / kg once. For skin diseases 3-5 injections at the rate of 10,000 IU / kg. For the prevention of viral, bacterial and fungal diseases, the drug is administered subcutaneously at the rate of 5000 IU / kg of body weight 1-2 injections with an interval of 48 hours. Prophylaxis is carried out 2 times a year with an interval of 6 months. For diseases of the urinary system, the drug is recommended to be used in complex therapy, 2-3 injections at a dose of 10,000 IU / kg with an interval of 24 hours. In case of late initiation of treatment, the course must be increased to five injections. In the case of cystitis, urolithiasis, the drug can be administered intercystically (intravesical). In case of polycystic kidney disease in cats, it is recommended to use 5 injections at a dose of 20,000 IU / kg in complex therapy with an interval of 48 hours. Repeat the course 30 days after the last injection. Roncoleukin is also used to prepare animals for exhibitions. It is recommended to use a dose of 5000 IU / kg twice with an interval of 24-48 hours. Last injection no later than 48 hours before the expected start of the exhibition. Roncoleukin should be prescribed as a maintenance therapy for old and debilitated animals. Once a quarter, 1-2 injections at the rate of 5000-10000 IU / kg. To stimulate innate immunity, especially in puppies and kittens with a weak sucking reflex, subcutaneous or oral administration at a dose of 5000 IU / kg once or twice with an interval of 24 hours is recommended. than 48 hours before the expected start of the exhibition. Roncoleukin should be prescribed as a maintenance therapy for old and debilitated animals. Once a quarter, 1-2 injections at the rate of 5000-10000 IU / kg. To stimulate innate immunity, especially in puppies and kittens with a weak sucking reflex, subcutaneous or oral administration at a dose of 5000 IU / kg once or twice with an interval of 24 hours is recommended. than 48 hours before the expected start of the exhibition. Roncoleukin should be prescribed as a maintenance therapy for old and debilitated animals. Once a quarter, 1-2 injections at the rate of 5000-10000 IU / kg. To stimulate innate immunity, especially in puppies and kittens with a weak sucking reflex, subcutaneous or oral administration at a dose of 5000 IU / kg once or twice with an interval of 24 hours is recommended.

Wild and exotic animals:
The drug is administered intravenously or subcutaneously at the rate of 10,000 IU / kg with an interval of 24-72 hours. Artiodactyl and callus (camels) animals are used in the same doses as in the treatment of cattle and small ruminants. Equid-hoofed animals are used in the same doses as in the treatment of horses. When treating exotic birds, you can use the intranosal method of drug administration.

For reptiles, the same doses are used as for rodents.

In the treatment of pinnipeds, doses of 3000-5000 IU / kg are used every 24-72 hours.

In the treatment of exotic birds, intranasal and oral administration methods can also be used.

Contraindications for
cattle and Horses with severe lesions of the conduction system and heart valve apparatus Roncoleukin is used with caution, fractionally. Myocardial infarction in cattle and horses is a contraindication for the use of Roncoleukin. Roncoleukin is not recommended to be administered to horses shortly before or immediately after exercise, or in hot weather due to the effect of hyperthermia. In malignant diseases of the blood and lymph, Roncoleukin should be used with caution.

Side effects
Subcutaneous injection of Roncoleukin may be accompanied by a short-term, up to 1 minute, painful reaction “burning”. In order to reduce this effect, water for injection should be used to dilute the drug.

Special instructions
Roncoleukin is compatible with most other drugs, but when using it, you should follow some rules: it is undesirable to administer Roncoleukin with any other drugs and vaccines in one syringe (except for vaccination of birds); do not administer Roncoleukin in solutions containing glucose, as the level of activity of the drug decreases.

It is not recommended to use Roncoleukin simultaneously with topical or systemic corticosteroid drugs.

Livestock products after application of the immunomodulator Roncoleukin can be used for food purposes without restrictions.

Storage conditions
An open vial of the drug is not subject to storage. The drug is stored in a dry, clean, dark place at a temperature of 2 to 10 ° C. The shelf life of the drug is 2 years from the date of manufacture. Transportation is allowed within 10 (ten) days at a temperature of 25 ° C.