Amprolinvet (amprolium hydrochloride) oral solution, 1000 ml

Description
Oily liquid from light yellow to dark yellow.

The composition
of 1 ml of the drug contains the active substance:
amprolium hydrochloride – 125.0 mg.

Pharmacological properties of
ATCvetQP51A, drugs against protozoan infections (QP52AX09, amprolium).
The active substance of the drug, amprolium hydrochloride, has a wide spectrum of anticoccidial activity, it is effective against chicken E. tenella, i.e. necatrix, i.e. acervulina, i.e. praecox, i.e. maxima, i.e. brunette, i.e. mitis; of turkeys – E. adenoeides, that is, gappapavonis, that is, meleagrimitis; pheasants – E. phasiani, i.e. colchici, i.e. duodenalis; rabbits – E. stiedae, that is, perforons, that is, magna; lambs – E. arloingii, that is, Ahsata, E. faurei; calves – E. bovis and E. zurnii.
The anticoccidial effect of amprolium is due to the fact that its chemical structure is close to thiamine (vitamin B1), which is necessary for the vital activity of Eimeria. In parasite cells, amprolium disrupts carbohydrate metabolism, which leads to their death.
It is known that amprolium hydrochloride mainly suppresses the development of Eimeria at the stage of schizogony of the first and second generation and is an antagonist of vitamin B1. It almost does not penetrate through the cell membranes of the intestinal mucosa of birds and mammals, so the drug is practically non-toxic in therapeutic doses. The main part of amprolium (up to 97%) is excreted from the body in an unchanged form. The drug suppresses the formation of immunity against coccidia, is compatible with vitamins and feed additives used in poultry farming.
Belongs to low-toxic compounds.

Application
Prevention and treatment of cattle (calves), sheep (lambs), rabbits (little rabbits up to 4-5 months of age), chickens, turkeys and pheasants in case of eimeria infection:
– In cattle (calves) – E. bovis and E. Zurnii;
-In sheep (lambs) – E. arloingii, that is, ahsata, that is, Faurei;
– In rabbits – E. stiedae, that is, perforons, that is, magna;
– In chickens – Eimeria teneila, that is, necatrix, that is, acervulina, that is, praecox, that is, maxima, that is, brunett and E. mit is;
-In turkeys – E. adenoeides, that is, gallapavonis, that is, meleagrimitis;
– In pheasants – E. phasiani, i.e. Colchici, i.e. duodenalis.

Dosage
The drug is drunk with drinking water in the following doses:
Broilers:
– prophylactically – 1 ml of the drug per 1 liter of drinking water (125 mg of amprolium hydrochloride per 1 liter of water) starting from 3-5 days of age during the growing period, excluding from the diet 3 days before slaughter; – treatment – 2 ml per 1 liter of drinking water (250 mg of amprolium hydrochloride per 1 liter of water) for 5-7 days.
Repair young chickens:
– prophylactically – 1 ml per 1 liter of drinking water (125 mg of amprolium hydrochloride per 1 liter of water) starting from 3-5 days of age up to 16 weeks of age; – treatment – 2 ml per 1 liter of drinking water (250 mg of amprolium hydrochloride per 1 liter of water) for 5-7 days.
Turkeys, pheasants:
– prophylactically – 1 ml per 1 liter of drinking water (125 mg of amprolium hydrochloride per 1 liter of water) starting from 1 day of age to 12 weeks of age or until the end of the period during which there is a threat of coccidiosis; – treatment – 2 ml per 1 liter of drinking water (250 mg of amprolium hydrochloride per 1 liter of water) for 3-5 days.
Rabbits:
– prophylactically – 2.5 ml / 10 kg of body weight during the period when there is a threat of coccidiosis; – treatment – 5 ml / 10 kg of body weight for 3-5 days.
Calves under 1 year and lambs:
– prophylactically – 1 ml / 10 kg of animal body weight during the period when there is a threat of coccidiosis; – treatment – 2 ml / 10 kg of animal body weight for 5-7 days.

*Kilograms to Pounds conversion table

After dilution in water, the drug is suitable for use within 16 hours.

Contraindication
Do not use in animals and birds with increased sensitivity to amprolium hydrochloride.
Do not use during pregnancy, lactation and pregnancy.
Do not use on weakened, exhausted and sick animals and poultry.

Warning
Slaughter of poultry and animals for meat is allowed 3 days after the last use of the drug, eggs for human consumption are allowed after 10 days. When slaughtering before the specified deadline, the meat is fed to unproductive animals or disposed of.

Release form
Ampoules made of neutral glass of the brands НС-1 and НС-2, USP-1 of 0.5 ml, 1 ml
Vials made of neutral glass of the brands НС-1, НР-2, USP-1, closed with rubber stoppers under an aluminum run-in 50 and 100 ml Secondary packaging – cardboard box.
Containers (vials) polymer according to TU U 23455985-001 of 500 ml and 1 l.

Storage
Store the drug in a place protected from light at a temperature of 5 to 25 ° C in the manufacturer’s container on racks or in tiers (no more than three).
Shelf life – 2 years.