Penbex Invesa Solution For Inj (penicillin procaine G, dihydrostreptomycin sulfate, betamethasone, chlorpheniramine maleate, procaine hydrochloride) – 100ml
Storage
Penbex is a complex antibacterial drug, 1 ml of which contains
penicillin procaine G – 200000 ME,
dihydrostreptomycin sulfate – 250 mg,
betamethasone – 0.5 mg,
chlorpheniramine maleate – 8 mg,
procaine hydrochloride and filler – 15 mg.
It is a sterile white suspension for injection.
During storage, sediment formation is allowed.
Pharmacological properties
The antibiotics penicillin procaine and dihydrostreptomycin sulfate, which are part of the drug, exhibit synergistic action, thereby increasing the effect of antibiotics and expanding the spectrum of the antimicrobial activity of the drug.
Penicillin procaine G belongs to the group of natural penicillins, it is active against gram-positive and gram-negative microorganisms, most anaerobic bacteria and spirochetes, including Staphylococcus spp., Streptococcus spp., Corynebacterium spp., Listeria spp., Pastorysida spp., Clostridium spp., , Leptospira strains Pomona, Grippotyphosa, Icterohaemorrhagiae, etc.
The mechanism of action of penicillin procaine G is to block the synthesis of peptidoglycan (the main component of the bacterial cell wall), leading to the death of the microorganism.
Dihydrostreptomycin sulfate is an antibiotic from the aminoglycoside group that has a pronounced bactericidal effect on gram-negative microorganisms, including Escherichia coli, Salmonella spp., Pasteurella spp., Klebsiella spp. The antibacterial effect of dihydrostreptomycin sulfate is based on the disruption of protein synthesis by the ribosomes of the microbial cell. After a single intramuscular injection of the drug penicillin, procaine and dihydrostreptomycin sulfate are absorbed into the blood and penetrate into the affected tissues of the animal, reaching maximum blood concentrations within an hour and remain at therapeutic concentrations for up to 24 hours. Antibiotics are excreted from the body mainly with urine and bile, in lactating animals, partially with milk.
Betamethasone inhibits the activity of phospholipase, and also helps to suppress inflammation at the site of the lesion. Chlorpheniramine maleate acts as an antihistamine, and also increases the protective functions of the body in diseases of the respiratory tract. According to the degree of impact on the body of warm-blooded animals, Penbex belongs to moderately hazardous substances.
Indications
Assign to large and small ruminants, horses, pigs, dogs and cats for the treatment of acute and chronic diseases of the respiratory system, genitourinary system, musculoskeletal system, colibacillosis, salmonellosis, pasteurellosis, gastroenterocolitis, mastitis, operating rooms, wounds, postpartum and other primary and secondary infections of bacterial etiology, the causative agents of which are sensitive to penicillin and streptomycin.
Doses and method of administration
Penbex is administered to animals deeply intramuscularly once a day in the following doses:
adult cattle and horses at the rate of 1 ml per 20 kg of animal weight, in case of a severe course of the disease, as well as calves and foals weighing up to 60 kg at the rate of 1 ml of the drug per 10 kg of animal weight.
For small cattle, pigs, dogs and cats, Penbex is used at the rate of 1 ml of the drug per 10 kg of animal weight.
The course of treatment is 3 – 5 days.
The maximum volume of the drug for administration in one place should not exceed 20 ml for cattle and horses, 10 ml for pigs, 5 ml for calves and sheep, and 2.5 ml for piglets.
Before use, the contents of the vial are thoroughly shaken until a homogeneous suspension is obtained.
If no noticeable clinical improvement occurs within 2 to 3 days, it is recommended to retest for the sensitivity of microorganisms to penicillin and dihydrostreptomycin.
Side effects
In some animals, at the injection site, a local reaction may appear in the form of itching, erythema, edema, which disappear spontaneously after the drug is discontinued.
Contraindications
Hypersensitivity to penicillin antibiotics and aminoglycoside antibiotics. Renal and cardiovascular failure. Simultaneous or sequential use of Penbex with other ototoxic and nephrotoxic drugs (neomycin, kanamycin, gentamicin) is not allowed due to the possible increase in oto- and nephrotoxic effects. The drug is not recommended to be administered to females in the last third of pregnancy.
special instructions
Slaughter of animals for meat, which used Penbex, is allowed 30 days after the last injection of the drug. In the event of the forced slaughter of animals before the established date, the meat is used to feed fur-bearing animals or for the production of meat and bone meal. Milk must not be used for food purposes during the treatment period and within 3 days after the drug is discontinued. Such milk can be used for feeding animals after heat treatment.
Release form
Bottles of 10, 50, 100 and 250 ml.
Storage conditions
Store in a dry, dark place and out of reach of children at temperatures from 5 to 25 ºС.
Shelf life is 3 years.