KSILA 2%, 50 ml (xylazine hydrochloride, XylaMed analog) Solution for injection, 50 ml

Description:

Transparent sterile injection solution.

Structure:

1 ml of the drug contains active ingredients:

• xylazine hydrochloride – 23.3 mg

Excipients: sodium metabisulfite, citric acid, hydrogen peroxide, benzyl alcohol, sodium hydroxide, water for injection.

Pharmacological properties:

ATCvet Classification Code: QN05CM – Other veterinary hypnotics and sedatives.

The drug has a sedative, analgesic effect, and also acts as a muscle relaxant. Xylazine is an α2-adrenergic agonist. The drug acts on the central nervous system by activating α2-adrenergic receptors, which leads to a decrease in the release of norepinephrine. By stimulating α2-adrenergic receptors, xylazine has analgesic and sedative effects. Also, the drug causes relaxation of skeletal muscles by blocking the intraneural transmission of impulses in the central nervous system.

Application:

For premedication before surgery, as a sedative for aggressive animals before examination and transport, to relieve pain in cattle, horses, sheep, dogs and cats.

Dosage:

Intravenous, intramuscular, subcutaneous.

Cattle – intramuscularly:

• Dose I – 0.25 ml of the drug per 100 kg of animal body weight – for sedation, slight relaxation, moderate analgesia for small operations.
• Dose II – 0.5 ml of the drug per 100 kg of animal body weight – causes moderate sedation, muscle relaxation and analgesia, which are sufficient for small operations on milking, hooves (panaritium) and others. The ability to stand is retained.
• Dose III – 1 ml of the drug per 100 kg of animal body weight – a strong manifestation of all effects; used for complex surgical interventions, in combination with additional local or local anesthesia. The ability to stand is not preserved in most cases.
• Dose IV – 1.5 ml of the drug per 100 kg of animal body weight – should be administered only in exceptional cases, after preliminary fasting for several hours, in very painful or prolonged operations, as well as to achieve a longer period of sedation and especially strong muscle relaxation … This dose is used in individual cases.
• *Kilograms to a Pounds conversion table
  

  Kilograms (kg)	Pounds (lb)	Pounds+Ounces (lb+oz)
  0.1 kg	0.220 lb	0 lb 3.527 oz
  1 kg	2.205 lb	2 lb 3.274 oz
  5 kg	11.023 lb	11 lb 0.370 oz
  10 kg	22.046 lb	22 lb 0.740 oz

Horses:

• intravenously 4 ml of the drug per 100 kg of animal body weight, intramuscularly 10 ml of the drug per 100 kg of animal body weight.

In complex operations, Xila is used in combination with other anesthetics intravenously at a dose of 4 ml of the drug per 100 kg of animal weight and inhalation anesthesia.

Sheeps:

• intramuscularly at a dose of 0.15 ml of the drug per 10 kg of animal body weight.

Dogs:

• intramuscularly or intravenously at a dose of 0.15 ml of the drug per 1 kg of animal body weight. The drug can be used with ketamine: 0.1 ml of Xyl per kg of animal weight and 6.0-10.0 mg of ketamine per kg of animal body weight

Cats:

• intramuscularly or subcutaneously at a dose of 0.15 ml of the drug per 1 kg of animal body weight. The drug can be used with ketamine, in the same combination as for dogs.

Contraindications:

• Do not use on animals with impaired heart function and during pregnancy.
• Do not use in case of respiratory system diseases.
• Do not use in diabetes mellitus (xylazine lowers insulin levels).
• Do not use in conditions of obstruction of the esophagus in dogs and cats. Use very carefully for convulsions, acute kidney or liver failure.
• From the reasons for the danger of cardiac arrhythmias, xylazine cannot be administered simultaneously with adrenaline and other drugs that excite the sympathetic system or immediately after their introduction.

Caveats:

Slaughter of animals for meat is allowed 3 days after the last use of the drug. Milk consumption by humans is allowed 2 days after the last use of the drug. Meat and milk received before the specified period are disposed of or fed to unproductive animals, depending on the conclusion of the veterinary doctor

Release form:

Bottles made of transparent glass are closed with a rubber stopper for an aluminum rim of 50 ml.

Storage:

Dry, dark place at temperatures from + 15 ° С to + 25 ° С.

After the first selection from the bottle, the drug must be used within 14 days, provided that it is stored in a dark place at a temperature of + 2 ° C to + 8 ° C.

Expiration date: 3 years.