Sanoderm ointment, 15 g (dipropionate, clotrimazole, gentamicin)
Description
Cream is white or off-white.
Structure
1 g of the drug contains active ingredients (mg):
betamethasone dipropionate (in terms of 100% substance) 0.64;
gentamicin sulfate (in terms of anhydrous gentamicin) 1;
clotrimazole (in terms of 100% substance) 10.
Excipients: methylparaben (methyl parahydroxybenzoate) (E 218) – 2 mg, propylene glycol, disodium edetate, mineral oil, white soft paraffin, cetostearyl alcohol, macrogol 20 cetostearyl ether, sodium dihydrogen phosphate monohydrate water, sodium hydrogen phosphate, dodecahydrate.
Pharmacological properties
Thanks to the combination of active ingredients, the drug has anti-inflammatory, anti-allergic, antibacterial, antifungal effects.
Betamethasone dipropionate is a synthetic fluoride corticosteroid. Has anti-inflammatory, glucocorticoid, anti-allergic, antipruritic action. When used topically, it narrows blood vessels, eliminates itching, slows down the release of inflammatory mediators (iseosinophils, smooth cells), interleukins 1 and 2, y-interferon (from lymphocytes and macrophages), inhibits hyaluronidase activity and reduces the permeability of the vascular walls. Metabolized in the liver. It is excreted by the kidneys, partially excreted in milk.
Clotrimazole – belongs to the group of imidazole antifungal drugs. Promotes an increase in the permeability of the phospholipid membrane of liposomes, vacuolization of the cytoplasm, and a decrease in the number of ribosomes. Active against: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furtur (Pityrosporum orbiculare).
Gentamicin is a broad-spectrum antibiotic from the aminoglycoside group that acts bactericidal against gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp., Staphylococcus aureus.
With external use of the drug Sanoderm in therapeutic doses, transdermal absorption of active substances into the blood is very unlikely. The use of occlusive dressings significantly increases the transdermal absorption of betamethasone and gentamicin, which may lead to an increased risk of systemic side effects.
Application
For the treatment of dogs and cats with dermatoses with a pronounced allergic, inflammatory reaction, itching, hyperemia, edema, infiltration of exudate, complicated by a secondary bacterial infection; fungal diseases of the skin: dermatophytosis caused by Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes, candidiasis caused by Candida albicans, Candida parapsilosis, the defeat of the yeast Malassezia furtur.
Dosage
The cream is applied topically. The dose of the drug depends on the area of the affected area. Before applying the cream, the hair on the affected area is cut off. The cream must be applied to the affected skin and surrounding areas with a thin layer 2 times a day (morning and evening), gently rubbing into the skin; after achieving clinical improvement, the frequency of drug use can be reduced to 1 time per day.
The duration of treatment is determined by the elimination of the inflammatory process and negative data of bacterial and / or mycological analysis, cessation of itching, skin cleansing.
The course of treatment depends on the type and severity of the course of the disease, the effectiveness of therapy, is determined by the veterinary doctor and usually takes 2-4 weeks (no more); a break of at least 20 days is required between repeated courses.
Contraindication
Hypersensitivity to the components of the drug.
Side effect
Excessive and prolonged use of the drug on a large surface of the skin can lead to the manifestation of systemic effects characteristic of the use of glucocorticosteroids, namely: oppression of the hypothalamic-pituitary-adrenal system with the development of secondary adrenal insufficiency, manifestations of symptoms of hypercortisolism (weight gain, edema, hypertension, glucosuria , hypokalemia), the occurrence of Itsenko-Cushing’s syndrome.
Warning
Avoid contact with eyes, open wounds.
Do not apply the cream to the skin around the eyes.
Release form
Tube of 15 g. 1 tube in a pack.
Storage
In original packaging, at a temperature not exceeding 25 ° С. Do not freeze.
The shelf life of the drug is 3 years.
For use in veterinary medicine!