Alizin Virbac, 10 ml (aglepristone)

Composition and form of release

As an active ingredient, 1 ml of the drug contains 30 mg of aglepristone, as auxiliary substances – ethanol 0.1 ml and peanut oil up to 1 ml.

Alizin is produced packaged in 10 ml each in glass vials, sealed with chlorobutanol stoppers and rolled up with aluminum caps.

Pharmacological properties

Pharmacological group: hormones and their antagonists. Part of Alizin ^®Aglepristone is a synthetic steroid that is a progesterone antagonist. Aglepristone blocks progesterone receptors in the uterus, disrupting the normal physiological process of maintaining pregnancy in bitches, resulting in abortion or fetal resorption. The ability of aglepristone to bind to uterine progesterone receptors in dogs is 3 times higher than that of progesterone. Aglepristone does not change the concentration of progesterone, prostaglandins, oxytocin or cortisol in the blood plasma within 24 hours after its administration, but promotes the release of prolactin within 12 hours after injection. The maximum concentration of aglepristone is observed in the blood 2.5 days after the administration of the drug. Aglepristone bio is transformed in the liver and excreted from the body mainly with feces.

Indications

Used to terminate unwanted pregnancies in pets up to 45 days after accidental mating. Alizin is also used to treat pyometra in dogs and cats without surgery.

Doses and method of administration

Alizin is applied after the end of the estrus period. The drug is administered to dogs under strictly aseptic conditions, subcutaneously at the withers, twice, with an interval of 24 hours at a dose of 10 mg / kg of animal weight (0.33 ml of solution per 1 kg of animal weight). For cats, the drug is administered at a dose of 10 mg / kg body weight once every 24 hours.

Doses of Alizin, with a volume of more than 5 ml, should be injected at different points.

Duration of taking the drug: dogs – 0-45 days of gestation, cats – 7-8 days after mating.

The effectiveness of the drug is 99% (when used up to the 25th day) and 96% (when used up to the 45th day).

The dose of the drug, depending on the weight of the animal, is:

After the injection of the drug, it is necessary to lightly massage the injection site. If the volume of the injected solution exceeds 5 ml, then the drug must be injected at several points. Abortion (or fetal resorption) occurs within 7 days after the administration of Alizin.

After application, a second visit is required for examination and confirmation of termination of pregnancy by ultrasound examination. In case of early termination of pregnancy – 20 days after treatment, in the middle term – after 8 days. In the case of incomplete abortion, treatment (2 injections of Alizin at a dose of 0.33 ml / kg / day with an interval of 24 hours) can be repeated 10 days later, between 30 and 45 days of pregnancy.

After using the drug, subsequent estrus passes in accordance with the physiological norm, which ensures unhindered pregnancy and childbirth.

Side effects

With increased individual sensitivity in animals, allergic reactions are possible. With the introduction of Alizin, local inflammation and pain at the injection site may occur. In bitches, when treated after the twentieth day of pregnancy, abortion may be accompanied by signs of physiological labor, that is, expulsion of the fetus, a slight loss of appetite and milk stagnation.

Contraindications

Individual hypersensitivity of the animal to aglepristone. The drug should not be used in dogs with impaired liver, kidney and adrenal function, as well as in patients with diabetes.

special instructions

When working with the drug Alizin, you should follow the general rules of personal hygiene and safety measures provided for when working with drugs for animals.

Storage conditions

Alizin ^{® is} stored in the manufacturer’s sealed packaging, in a dry, dark place, out of reach of children and animals, separately from food and feed at a temperature of 15 ° C to 25 ° C. The shelf life of the medicinal product, subject to storage conditions, is 3 years from the date of production. After the first opening of the bottle, the drug can be used for no more than 28 days, subject to the rules of asepsis and storage at a temperature of 3 ° C to 5 ° C.