Toltradox Toltrazuril Oral Suspension , 100 ml
Toltrazuril treatment coccidia for Dogs, Cattle, Sheep, Rabbits, Pigs, and Goats
Toltradox for the treatment and prevention of coccidiosis in animals
Composition
Toltrazuril 50 mg/ml, additives up to 1 ml.
Indications
Toltradox is used in dog puppies and fur animals in the treatment and prevention of coccidiosis.
Pharmacological properties
Toltradox is one of the anti-coccidial drugs of the triazintrione group.
Toltrazuril, which is part of the drug, has a wide spectrum of coccidial action at the stages of intracellular development of parasites, is effective against all types of coccidia, including Eimeria spp., Isospora spp., Cistoisospora spp., Parasitizing in pigs, calves, lambs and dog puppies.
Toltrazuril has a damaging effect on mitochondria and the processes of fission of the nucleus of coccidia, disrupting the formation of macrogametocytes, blocking respiratory enzymes, and causing the death of parasites.
After oral administration of the drug, toltrazuril is slowly absorbed and has a coccidiocidal effect on the mucosa and submucosa of the gastrointestinal tract.
In the body, toltrazuril is metabolized by sulfoxidation and hydroxylation, with the formation of sulfoxide and sulfone. It is excreted from the body mainly unchanged – up to 70%, as well as in the form of metabolites with feces and partly with urine.
Toltradox, according to the degree of impact on the body, belongs to low-hazard substances, in recommended doses does not cause side effects and complications in animals does not interfere with the formation of immunity to coccidiosis.
Application
Toltradox is prescribed to calves, lambs, kids, piglets, and puppies of dogs for the treatment and prevention of coccidiosis.
Contraindication to the use of Toltradox is the increased individual sensitivity of the animal to the components of the drug, serious violations of the liver and/or kidneys.
It is forbidden to use the drug in dairy animals, due to its excretion in milk; the drug should not be used in adult ruminants with developed cicatricial digestion.
Dosage and administration
Toltradox is administered to animals orally individually using a syringe dispenser or mixed with a small amount of feed. If there is sediment, the container with suspension should be thoroughly shaken before use.
Doses and administration patterns of the drug are as shown in the table:
| Animals | Age | Dose, per kg of animal | Administration | |
| body weight | ||||
| Toltrazuril mg | Preparation, ml | |||
| Dog, puppies | from 14 days | 10 | 0,2 | Once daily, three days |
| Rabbit | from 28 days | 7 | 0,14 | Single dose |
| Mink | from 28 days | 20 | 0,4 | Single dose |
| Foxes and | from 28 days | 10 | 0,2 | Single dose |
| Arctic foxes | ||||
| Calves, lambs, and goats | from 14 days | 15 | 0,3 | Single dose |
| Piglets | from 3 days | 20 | Single dose | |
| 0,5-2 | ||||
*Kilograms to a Pounds conversion table
| Kilograms (kg) | Pounds (lb) | Pounds+Ounces (lb+oz) |
| 0.1 kg | 0.220 lb | 0 lb 3.527 oz |
| 1 kg | 2.205 lb | 2 lb 3.274 oz |
| 5 kg | 11.023 lb | 11 lb 0.370 oz |
| 10 kg | 22.046 lb | 22 lb 0.740 oz |
Special indications
In dysfunctional farms for coccidiosis, in order to achieve the maximum preventive effect and reduce the number of oocysts released into the environment, the drug should be administered to susceptible animals before the first clinical signs of the disease appear in the herd.
In case of an overdose of the drug, the animal may experience a decrease in appetite, a decrease in water consumption, and an upset of the gastrointestinal tract.
Failure to comply with the recommended interval for repeated administration of the drug to puppies can lead to a decrease in its effectiveness. If the next dose of the drug is missed, it should be administered as soon as possible.
When using Toltradox in accordance with this instruction, side effects and complications in animals, as a rule, are not observed. With increased individual sensitivity to the drug and the appearance of allergic reactions, the animal is prescribed antihistamines and symptomatic therapy.
Toltradox should not be used concurrently with other anti-coccidial drugs. There is no information about the incompatibility of the drug with drugs of other groups and feed additives.
The veterinary drug should not be used in case of hypersensitivity to the components, including previously identified. Also, the drug is contraindicated:
– in case of violations in the liver and / or kidneys;
– adult ruminants with developed digestion;
– laying hens – the active substance accumulates in the eggs.
Use in carrying offspring is possible on the recommendation of a doctor, in the second half of the gestation period.
It is forbidden to feed at the age of:
younger than 3 days – for young pigs;
younger than 14 days – for puppies of dogs, calves, lambs, and kids;
younger than 28 days – for rabbits, minks, arctic foxes and foxes;
older than 16 months – for replacement hens.
Withdrawal period
Slaughter of calves, lambs, goats, and rabbits for meat is allowed no earlier than after 63 days, piglets — no earlier than after 70 days after the last administration of Toltradox. Meat of the animals slaughtered before the end of the specified periods may be used as feed for fur animals.
Contraindications
Contraindication to the use of Toltradox increased individual sensitivity of the animal to the components of the drug, severe impairment of the liver and/or kidney function.
The drug should not be used in adult ruminants with developed cicatricial digestion.
Storage
Store sealed in the factory packaging, protected from direct sunlight, separately from food, and feed at a temperature between 0 ºС and 25 ºС.
Shelf life
The shelf life looks on the package.
For use in veterinary medicine!
