Trade name of the medicinal product: Denagard® 10% injection solution. International non-proprietary name: tiamulin.
Dosage form: injection solution.
Denagard 10% injection solution as an active ingredient (DV) in 1 ml contains tiamulin base – 100 mg and excipients: sesame (sesame) oil – 771 mg, propyl galate – 0.1 mg, glycerol monooleate – 20 mg and ethanol – up to 1 ml. In appearance, the drug is a clear oily solution of yellowish color.
The drug is produced in glass vials.
Store the drug in the manufacturer’s sealed packaging, separately from food and feed, in a dry place protected from direct sunlight, at a temperature of 15 ° C to 25 ° C.
The shelf life of the drug, subject to storage conditions in a sealed package, is ~ 5 years from the date of production, after opening the package – 28 days.
Denagard 10% injection solution is prohibited to use after the expiration date.
Denagard® 10% injection solution should be stored out of the reach of children.
The unused drug is disposed of in accordance with legal requirements.
Pharmacological properties
Denagard® 10% injection solution belongs to the antibiotics from the pleuromutilin group. Tiamulin, which is part of the drug, has bacteriostatic activity, suppressing protein synthesis of the microbial cell at the ribosomal level, and is highly active against mycoplasmas, including M. hyopneumoniae, M. hyosynoviae, M. hyorhinis, spirochetes (B, hyodysenteriae, B. pilosicoli), gram-positive aerobes, including Staphylococcus spp., Streptococcus spp., Corynebacterium pyogenes and anaerobes (Clostridium spp.), gram-negative anaerobes including Lawsonia intracellularis, Bacteroides spp., Fusobacterium spp. and aerobes (Actinobacillus pleuropneumoniae, Pasteurella multocida); ns acts on bacteria of the Enterobacteriaceae family, including Salmonella spp. and Escherichia coli.
After intramuscular administration of the drug, tiamulin is rapidly absorbed from the injection site and penetrates into most organs and tissues, reaching maximum concentrations in the body of pigs after 1.5-2 hours. It is excreted from the body mainly with feces.
Denagard® 10% injection solution according to the degree of impact on the body refers to moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76).
The order of application
Denagard® 10% injection solution is prescribed to pigs with a therapeutic purpose for dysentery, enzootic pneumonia, pleuropneumonia and infectious arthritis.
A contraindication to the use of the drug is the increased individual sensitivity of the animal to tiamulia. The drug should not be used in pigs with severe hepatic and renal impairment.
Denagard® 10% injection solution is administered to pigs intramuscularly once a day in the following doses:
– for dysentery caused by B. hyodysenteriae, including those complicated by Bacteroides spp. or Fusobacterium spp. – 8 mg of tiamulin base per 1 kg of animal weight, which corresponds to 1 ml of the drug per 12.5 kg of animal weight, for 1-2 days.
– for enzootic pneumonia caused by M. hyopneumoniae, including complicated by Pasteurella multocida or Actinobacillus pleuropneumoniae, and infectious arthritis caused by M. hyosynoviae – 12.3 mg of tiamulin base per 1 kg of animal weight, which corresponds to 1.5 ml of the drug per 12 , 5 kg of animal weight, within 3 days.
– for pleuropneumonia caused by Actinobacillus pleuropneumoniae – 12.3 mg of tiamulin base per 1 kg of animal weight, which corresponds to 1.5 ml per 12.5 kg of animal weight, for 2-3 days.
In case of an overdose of the drug in animals, diarrhea, anorexia, and nephrotoxic effects may occur. In these cases, the use of the drug is discontinued and the animal is prescribed symptomatic therapy.
The peculiarities of the action of the drug during its first use and cancellation have not been established.
Avoid skipping the next dose of the drug, as this can lead to a decrease in therapeutic efficacy. If one dose is missed, the use of the drug should be resumed as soon as possible in the same dosage and according to the same scheme.
When using the drug in accordance with this instruction, side effects and complications, as a rule, are not observed. In rare cases, the animal at the injection site may have erythema and slight edema of the skin, which disappear within 1-3 days without the use of drugs. In case of allergic reactions, the use of the drug is discontinued and antihistamines and symptomatic therapy are prescribed.
It is not allowed to use Denagard® 10% injection solution together with polyester ionophores, incl. monensin, narasin and salinomycin, as well as for 7 days before and 7 days after the use of these drugs, due to the possible occurrence of side effects and complications in animals, which can lead to a significant slowdown in the growth and death of animals.
Slaughter of pigs for meat is allowed no earlier than 16 days after the last application of Denagard® 10% injection solution. The meat of animals that were forcedly killed earlier than the specified period can be used as feed for fur animals.