Milprazon (milbemycin oxime, praziquantel) for cats over 2 kg, 16 mg / 40 mg, 2 tablets
Description
Film-coated tablets, biconvex, oval, yellow-brown in color, with a notch on one side.
Structure
1 tablet contains active ingredients:
milbemycin oxime – 16 mg,
praziquantel 40 mg
Excipients: yellow iron oxide (E172), titanium dioxide (E171), microcrystalline cellulose, lactose, povidone, croscarmellose sodium, colloidal silicon, magnesium stearate, hypromellose, talc, propylene glycol, meat flavor, yeast powder.
Pharmacodynamics
Milprazone is a combined anthelmintic drug of nematicidal and cestocidal action. The active substances that make up the drug determine its wide spectrum of anthelmintic action.
Milbemycin oxime is a macrocyclic lactone obtained from the fermentation of Streptomyces hygroscopicus, type Aureolacrimosus, is active against larvae and imago of nematodes parasitizing in the alimentary canal of cats, as well as against larvae of nematodes Dirofilaria immitis (microdirofilariae). The mechanism of action of milbemycin is due to an increase in the permeability of cell membranes for chloride ions (Cl-), which leads to polarization of the membranes of the cells of the nervous and muscle tissue, paralysis and death of the parasite.
Praziquantel is an acylated pyrazinisoquinoline derivative. Praziquantel is active against cestodes and trematodes. By increasing the permeability of the parasite’s cell membranes for calcium ions (Ca2 +), it causes membrane depolarization, muscle contraction and destruction of the tegument, which leads to the death of the parasite and promotes its excretion from the animal body.
Pharmacokinetics
After oral administration of the drug, the maximum concentration of milbemycin oxime in the blood plasma of cats is reached within 2 hours, it is excreted from the body of animals mainly unchanged, the half-life is about 13 hours.
After oral administration of the drug, the maximum concentration of praziquantel in blood plasma is reached after 1 hour, the compound is excreted from the body mainly in the form of inactive metabolites by urine, the half-life is 3 hours.
In rats, the metabolism is complete, but slow, since unchanged milbemycin oxime was not exhibited in urine or feces. The main metabolites in rats are monohydroxylated derivatives associated with hepatic biotransformation. In addition to the relatively high concentrations in the liver, there is some level of concentration in fat, which indicates that the substance is lipophilic.
Milprazone, according to the degree of effect on the body of cats, belongs to moderately toxic substances (safety class 3), in the recommended doses it does not have a sensitizing, embryotoxic and teratogenic effect, is well tolerated by cats of different breeds and ages. The drug is toxic to bees, as well as fish and other aquatic organisms.
Application
Prevention and treatment of cats with invasions caused by cestodes (larval and sexually mature forms) – Dipylidium caninum, Taenia spp., Echinococcus spp.; nematodes – Ancylostoma tubaeforme, Toxocara cati, Dirofilaria immitis (disease prevention) incl. with combined nematode-cestode invasions.
The drug can also be used to prevent heartworm disease (Dirofilaria immitis) if concomitant treatment against cestodes is indicated.
Dosage
The drug is administered to cats once during feeding with a small amount of food or injected forcibly onto the root of the tongue after feeding in a minimum therapeutic dose of 2 mg of milbemycin oxime and 5 mg of praziquantel per kg of body weight.
Depending on the body weight of the cats, the actual dosage is:
Body mass | The amount of the drug |
2 – 4 kg | ½ tablet |
> 4 – 8 kg | 1 tablet |
> 8 – 12 kg | 1½ tablets |
A preliminary fasting diet and the use of laxatives before deworming are not required.
For therapeutic purposes, cats are dewormed according to indications, for prophylactic purposes – on a quarterly basis, as well as before each vaccination and mating in a therapeutic dose. A single therapeutic dose protects cats from Dirofilaria immitis infection for up to one month. For the subsequent prevention of dirofilariasis, it is advisable to use a drug containing one active ingredient milbemycin oxime.
The peculiarities of the drug’s action during its first use and cancellation have not been established. When carrying out deworming, it is necessary to adhere to the recommended timing. In case of skipping the next treatment, the use of the drug is resumed in the same dose and according to the same scheme.
Contraindications
Hypersensitivity of animals to the components of the drug (including in the anamnesis)!
Severe renal and liver dysfunctions!
Do not use for kittens under 6 weeks old and / or weighing less than 0.5 kg!
Do not apply to animals that are exhausted and sick with infectious diseases!
Warning
Deworming of cats during pregnancy and lactation is carried out if necessary and under the supervision of a veterinarian.
It is recommended to process all animals that are in the same farm.
In order to develop an effective deworming program for cats, it is necessary to take into account the local epizootic situation and conditions of keeping animals, and conduct deworming under the supervision of a veterinarian.
In regions with a risk of dirofilariasis (D. caninum), it is necessary to simultaneously treat animals against intermediate hosts, which are mosquitoes of the genera Anopheles, Aedes, Culex, to prevent re-infection.
The use of the drug in weakened cats or with impaired renal or liver function is carried out after assessing the benefit / risk ratio under the supervision of a veterinarian.
form of issue
Blisters from OPA / Al / PVC foil of cold stamping and aluminum foil of 2, 4 and 48 tablets.
Storage
The drug is stored in the original packaging of the manufacturer, separately from food and feed, in a dry, protected from direct sunlight, out of the reach of children and animals, at a temperature of 5 to 25 ° C. The halved tablets should be stored at temperatures up to 25 ° C in the original blister. Store blister in outer carton.
Shelf life
3 years. The shelf life of halved tablets after opening the primary packaging is 6 months.
For use in veterinary medicine!