Milpro 4 mg / 10 mg (milbemycin oxime, praziquantel) for kittens up to 2 kg, 24 tablets
Milpro for cats contains milbemycin oxime and praziquantel as active substances. The drug is available in two modifications: Milpro ket for kittens containing milbemycin oxime – 4 mg / tablet, and praziquantel – 10 mg / tablet. and Milpro cat for cats containing milbemycin oxime – 16 mg / tablet, and praziquantel – 40 mg / tablet.
As excipients Milpro ket tablets for cats and kittens in 1 tablet contain: microcrystalline cellulose, croscarmellose sodium, povidone, magnesium stearate, hydrophobic colloidal silicon dioxide, hypromellose, macrogol, titanium dioxide, food additives AC (E129) – in Milpro cat for cats and iron oxide – in Milpro cat for kittens.
Pharmacological properties
Pharmacotherapeutic group of the drug: combined anthelmintic drugs of nematode and cestode action.
Milbemycin oxime, which is part of the drug – a macrocyclic lactone, obtained by the enzymatic activity of Streptomyces hygroscopicus var. Aureolacrimosus, active against larvae and adults of nematodes parasitizing in the gastrointestinal tract of cats, as well as larvae of the nematode Dirofilaria immitis.
The mechanism of action of milbemycin is due to increased permeability of cell membranes for chlorine ions, which leads to overpolarization of cell membranes of nerve and muscle tissue, paralysis and death of the parasite. After oral administration of the drug, the maximum concentration of milbemycin oxime in blood plasma is reached after 2 hours, the compound is excreted mainly unchanged, the half-life is 32-48 hours.
Praziquantel is an acylated derivative of pyrazine-isoquinoline, has a pronounced effect against cestodes and nematodes. Increasing the permeability of the parasite’s cell membranes to calcium ions, causes depolarization of the membranes, muscle contraction and destruction of the tegument, which leads to the death of the parasite and promotes its excretion from the animal.
After oral administration of the drug, the maximum concentration of praziquantel in the blood plasma of cats is reached after 1 hour, the compound is excreted mainly in the form of inactive metabolites in the urine, the half-life is about 3 hours.
In the recommended doses do not have sensitizing, embryotoxic and teratogenic effects, well tolerated by cats of different breeds and ages.
The drug is toxic to fish and other aquatic organisms.
The order of application
Milpro ket is prescribed for therapeutic and prophylactic purposes in nematodes, cestodes and mixed nematode-cestode infestations caused by both larval forms and mature cestodes and nematodes of the following species:
- Цестоди: Dipylidium caninum, Taenia spp., Echinococcus multilocularis
- Nematodes: Ancylostoma tubaeforme, Toxocara cati, Dirofilaria immitis (prevention of the disease for 1 month)
Contraindications to the use of the drug Milpro ket are hypersensitivity of the animal to the components of the drug and severe liver and kidney dysfunction.
Milpro cat for kittens should not be used in kittens under 6 weeks of age and weighing less than 0.5 kg; Milpro cat for cats – cats weighing less than 2 kg.
Exhausted and infectious animals are not subject to deworming.
Deworming of pregnant and lactating cats, if necessary, is carried out under the supervision of a veterinarian.
Dosage
Milpro ket is used once during feeding with a small amount of food or forcibly administered to the root of the tongue after feeding in a minimum therapeutic dose of 2 mg milbemycin oxime and 5 mg praziquantel per 1 kg of animal weight at the rate of:
Animal weight, kg | Milpro cat for kittens (brown) | Milpro cat for cats (from red to pink) |
0.5-1 | 1/2 tablet | – |
1-2 | 1 tablet | – |
2-4 | – | 1/2 tablet |
4-8 | – | 1 tablet |
8-12 | – | 1.5 tablets |
Pre-starvation diet and the use of laxatives before deworming is not required.
For therapeutic purposes, cats are dewormed according to the indications, for prophylactic purposes – quarterly, as well as before each vaccination and mating in a therapeutic dose.
In case of overdose, some cats may experience tremor, the symptoms of which involuntarily disappear within a day and do not require the use of drugs.
Deworming of pregnant and lactating cats, if necessary, is carried out under the supervision of a veterinarian.
When carrying out deworming it is necessary to adhere to the terms recommended by the instruction. In case of skipping the next treatment, the drug is resumed in the same dose according to the same scheme.
Side effects and complications with the use of the drug in accordance with these instructions, as a rule, are not observed.
In some cats (more common in kittens), lethargy, ataxia, muscle tremor, vomiting, and / or diarrhea may occur. In these cases, the drug is discontinued and the animal is prescribed symptomatic therapy.
Milpro ket is compatible with selamectin, there is no experience on the compatibility of the drug with other macrocyclic lactones.
The drug is not intended for use in productive animals.
Personal prevention measures
When working with Milpro ket should follow the general rules of personal hygiene and safety, provided when working with drugs.
People with hypersensitivity to the components of the drug should avoid direct contact with the drug Milpro ket.
In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they should be rinsed with plenty of water. In case of allergic reactions or accidental ingestion of the drug, you should immediately contact a medical institution (have instructions for use of the drug or label).
Storage
Shelf life of Milpro cat tablets
Subject to storage conditions in a closed package – 3 years from the date of manufacture. Unused half of the tablet can be placed in a blister and stored until the next deworming, but not more than 6 months after opening the package.
Do not use the drug after the expiration date.
Milpro cat is stored in the manufacturer’s closed packaging in a dark place at a temperature of 5 ° C to 25 ° C out of reach of children.