Ceftriaxone (ceftriaxone) powder for Injection 5g (1g*5pcs) O.L.KAR

Ceftriaxone (ceftriaxone) powder for Injection OLKAR

Description

Crystalline powder of almost white or yellowish color.

Composition

1 bottle contains active ingredient:

ceftriaxone sodium salt – 1.0 g

Pharmacological properties

Ceftriaxone is an antibiotic of the beta-lactam group, a third generation cephalosporin that has a bactericidal effect. The mechanism of action of the drug is associated with inhibition of the activity of the enzyme trapeptidase, disruption of the biosynthesis of peptidoglycan of the cell wall of microorganisms. The drug has a wide spectrum of action: active against gram-positive aerobic: Staphylococcus aureus (including strains producing penicillinase), Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans; gram-negative aerobes: Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella spp. (including K. pneumoniae), Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae, N. meningitidis, Proteus mirabilis, Proteus vulgaris, Serratia spp. (including Serratia marcescens), Acinetobacter calcoaceticus, Pseudomonas aeruginosa; obligate anaerobes: Bacteroides fragilis, Peptostreptococcus spp., Clostridium spp. (except for Clostridium difficile). It also has activity against most strains of the following microorganisms: Providenda spp., Bacteroides bivius, Bacteroides melaninogenicus, Salmonella spp. (including Salmonella typhi), Shigella spp., Streptococcus agaladiae, Providenda rettgeri, Citrobacter freundii. The drug is prescribed for microflora resistance to other drugs of the cephalosporin series, aminoglycosides, penicillins, etc. After administration, the drug is absorbed quickly and completely. The bioavailability of the substance is about 100%. Clostridium spp. (except for Clostridium difficile). It also has activity against most strains of the following microorganisms: Providenda spp., Bacteroides bivius, Bacteroides melaninogenicus, Salmonella spp. (including Salmonella typhi), Shigella spp., Streptococcus agaladiae, Providenda rettgeri, Citrobacter freundii. The drug is prescribed for microflora resistance to other drugs of the cephalosporin series, aminoglycosides, penicillins, etc. After administration, the drug is absorbed quickly and completely. The bioavailability of the substance is about 100%. Clostridium spp. (except for Clostridium difficile). It also has activity against most strains of the following microorganisms: Providenda spp., Bacteroides bivius, Bacteroides melaninogenicus, Salmonella spp. (including Salmonella typhi), Shigella spp., Streptococcus agaladiae, Providenda rettgeri, Citrobacter freundii. The drug is prescribed for microflora resistance to other drugs of the cephalosporin series, aminoglycosides, penicillins, etc. After administration, the drug is absorbed quickly and completely. The bioavailability of the substance is about 100%. Citrobacter freundii. The drug is prescribed for microflora resistance to other drugs of the cephalosporin series, aminoglycosides, penicillins, etc. After administration, the drug is absorbed quickly and completely. The bioavailability of the substance is about 100%. Citrobacter freundii. The drug is prescribed for microflora resistance to other drugs of the cephalosporin series, aminoglycosides, penicillins, etc. After administration, the drug is absorbed quickly and completely. The bioavailability of the substance is about 100%.

Application

Treatment in dogs and cats of diseases of the respiratory system, genitourinary system, skin, soft tissues and bones, otitis media, sepsis, meningitis caused by microorganisms sensitive to ceftriaxone; prevention of postoperative complications.

Dosage

The drug is administered intramuscularly or intravenously once a day.

For intramuscular administration to dogs, the contents of one vial (1.0 g of the drug) are dissolved in 3.6 ml of 1% lidocaine solution or 0.25% -0.5% novocaine solution or sterile water for injection. 1 ml of the solution prepared in this way contains about 250 mg of ceftriaxone.

For administration to cats, the contents of one bottle are dissolved in 3.6 ml of 0.25% -0.5% novocaine solution or sterile water for injection. When used, cats should not dissolve the drug with lidocaine. 1 ml of the solution prepared in this way contains about 250 mg of ceftriaxone.

For intravenous administration, the contents of the vial are dissolved in 9.6 ml of sterile water for injection or 0.9% sodium chloride solution, or 5% glucose solution. 1 ml of the solution prepared in this way contains about 100 mg of ceftriaxone.

For drip administration, the contents of the bottle are dissolved in 100-250 ml of 0.9% sodium chloride solution or 5% glucose solution. The infusion of the prepared solution is carried out for 20-30 minutes at an injection rate of 60-80 drops per minute.

The daily dose of the drug is 20-40 mg of ceftriaxone per 1 kg of animal body weight. If necessary, the frequency of use can be increased up to 2 times a day with a dosage of 10-20 mg of ceftriaxone per 1 kg of animal body weight. The course of use of the drug is 5-10 days, depending on the severity and course of the disease.

Contraindications

Hypersensitivity to drugs of the cephalosporin group and other beta-lactam antibiotics; renal or hepatic impairment; period of pregnancy.

Caveats

When dogs are treated with high doses of ceftriaxone, stones can form in the gallbladder. In case of hypersensitivity to lidocaine, it is not recommended to use its 1% solution as a solvent.

Release form

Glass vials, closed with rubber stoppers and aluminum caps for running-in, 1 g each, packed in cardboard boxes of 40 fl.

Storage

A dry, dark place, out of the reach of children, at a temperature of 15 ° C to 25 ° C.

Expiration date – 3 years from the date of manufacture.