Propalin 30ml

Properties and actions

Propalin’s active ingredient – phenylpropanolamine hydrochloride (FPA)- acts on alpha- and, to a lesser extent, on beta-adrenergic receptors, and also indirectly increases the release of norepinephrine from the depot. It has a direct effect on the muscles of the lower urinary tract (increases tone and enhances the contraction of the urethral sphincter). When administered orally, FPA is rapidly absorbed from the gastrointestinal tract. It is excreted from the body in the urine in unchanged form or in the form of inactive metabolites. FPA reaches its peak plasma concentration after 1–2 hours. There is no accumulation of the drug during the treatment period.

Indications

Propalin is used in dogs for urinary incontinence due to functional insufficiency of the urethral sphincter.

Contraindications

Propalin is contraindicated for puppy and lactating animals, with hypersensitivity to the components of the drug.

Undesirable effects

Side effects and complications when using Propalin in accordance with the instructions for use of the medicinal product have not been established.

Interaction

Propalin is not recommended to be used simultaneously with other sympathomimetics, anticholinergic drugs, tricyclic antidepressants.

Application and dosage

Propalin is used in a mixture with food during feeding at a dose of 0.03 ml per 1 kg of body weight 2 times a day, or 0.02 ml per 1 kg of body weight 3 times a day. For dogs weighing 25 kg or more Propalin is used in a dose of 0.75 ml per 25 kg of body weight 2 times a day, or 0.5 ml per 25 kg of body weight 3 times a day. Over time, the dose of the drug can be reduced on an individual basis.

Propalin is intended for continuous use.

Storage conditions

Propalin should be stored with caution in a dry place, protected from direct sunlight, at a temperature of 15 ° C to 25 ° C.

Shelf life is

24 months from the date of manufacture, subject to storage conditions.

The shelf life after opening the bottle is 3 months.

Special warnings

When working with Propalin, you should follow the general rules of personal hygiene and safety measures provided for working with medicinal products for animals.

Do not use empty vials and used dispensing syringes for household purposes. Propalin is not used after the expiration date. Propalin should be kept out of the reach of children.

For animals only

Packaging

Propalin is produced in the form of a 5% solution for oral administration and is packaged in plastic vials with a volume of 30 or 100 ml, which, complete with a syringe-dispenser, are packed in a cardboard box.

Instructions for the drug Propalin

Marketing authorization holder : VETOQUINOL, SA (France)

Active ingredient: phenylpropanolamine (phenylpropanolamine) Rec.INN registered by WHO

Dosage form: PROPALINE oral solution

reg. No.: 250-3-8.16-3360 No. PVI-2-3.5 / 01750 dated 06.08.2016 – Validity of reg. beats not limited

Product form, composition and packaging

Solution for oral administration transparent, colorless 1 ml, phenylpropanolamine hydrochloride 50 mg.

Excipients: sorbitol solution.

Propalin is packaged in 30 and 100 ml bottles, hermetically sealed with screw caps with first opening control. The vials are packed in individual cardboard boxes complete with a graduated dispenser with a capacity of 1.5 ml. Each consumer package is supplied with instructions for use.

Registration certificate number 250-3-8.16-3360 No. PVI-2-3.5 / 01750 dated 16.08.16

Pharmacological (biological) properties and effects

Propalin belongs to synthetic sympathomimetics of the amine group. Phenylpropanolamine hydrochloride , which is part of the drug, acts mainly on α-adrenergic receptors, indirectly increases the release of norepinephrine (norepinephrine) from the depot and, directly affecting the smooth muscles of the lower urinary tract, increases tone and enhances the contraction of the urethral sphincter.

Phenylpropanolamine hydrochloride is rapidly absorbed from the gastrointestinal tract, reaching a maximum concentration in the blood plasma of dogs within 1-2 hours after oral administration. It is excreted from the body through the kidneys unchanged and in the form of inactive metabolites.

According to the degree of impact on the body, propalin belongs to moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76).

Indications for use of the drug PROPALIN

Propalin is prescribed to sterilized (after ovariectomy / ovariohysterectomy) bitches with urinary incontinence associated with functional insufficiency of the urethral sphincter.

Application procedure

Propalin is administered orally, daily, in a daily dose of 0.06 ml per 1 kg of animal weight, which should be divided into 2 or 3 doses.

Avoid skipping the next dose of the drug, because this can lead to a decrease in its therapeutic effectiveness. If one or more doses are missed, the use of the drug must be resumed in the same dose according to the same scheme.

Side effects

When using the drug in accordance with the instructions, side effects and complications in animals, as a rule, are not observed.

In case of an overdose of the drug, the animal may experience tachycardia, arrhythmia, loss of consciousness. There are no specific detoxifying agents; apply general measures aimed at removing the drug from the body, symptomatic treatment.

Contraindications to the use of PROPALINE

A contraindication to use is the increased individual sensitivity of the animal to the components of the drug.

Special instructions and measures for personal prevention

In case of increased individual sensitivity of the animal to the components of the drug and the appearance of allergic reactions, the use of the drug is stopped and desensitizing therapy is carried out.

The drug is used only in sterilized bitches.

The simultaneous use of the drug Propalin with other sympathomimetics, anticholinergic agents and tricyclic antidepressants is prohibited.

The drug is not intended for use in production animals.