Tricilin (benzylpenicillin sodium salt, streptomycin sulfate, streptocide white)
6 g of the drug (1 vial) contain:
benzylpenicillin sodium salt – 500 thousand IU
streptomycin sulfate – 500 thousand IU
streptocide white – 5 g
Description
White powder, fine crystalline, with a specific odor.
Pharmacological properties
Combined drug with a broad spectrum of antimicrobial action against gram-positive bacteria – Streptococcus spp., Staphylococcus spp., Bacillus spp., Corynebacterium diphtheriae, to a lesser extent against Enterococcus spp., Gram-negative bacteria – Escherichla spp., Klebsterpa soli, Proteus. E. coli, Salmonella spp., Shigella spp., Yersinia spp., Haemophillus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Francisella tularensis, Pasteurella spp., Brucella spp., Corynebacterium, Corynebacterium spp. spp., listeria – Listeria monocytogenes, erysipelotrix – E. rhusiopathiae and spirochetes – Treponema spp., Borrelia spp., Leptospira spp.
Benzylpenicillin is a bactericidal antibiotic from the group of natural penicillins, prevents the formation of peptide bonds by inhibiting transpeptidase activity, disrupts the late stages of synthesis of peptidoglycan cell membrane, which leads to lysis of dividing cells.
Streptomycin is an aminoglycoside antibiotic with a broad spectrum of antimicrobial activity, binds to the 30S subunit of the bacterial ribosome, which leads to inhibition of protein synthesis in microorganisms.
Streptocide belongs to sulfanilamides, acts bacteriostatically, preventing the use of para-aminobenzoic acid by microorganisms for the synthesis of dihydrofolic acid, which is involved in the synthesis of pyramidine bases of DNA and RNA of microbial cells.
After use, benzylpenicillin penetrates well into body tissues and fluids, except for cerebrospinal fluid, internal environments of the eye and prostate. Approximately 55% of the total dose is bound to plasma proteins. Most (50-80%) are excreted by the kidneys unchanged (85-95%).
Streptomycin is almost non-binding to blood proteins, does not penetrate most cells and is distributed mainly in blood plasma and extracellular fluid, including abscess fluid, pleural effusion, ascites, pericardial, synovial, lymphatic and peritoneal fluid. Practically not subject to biotransformation. Excreted by the kidneys by glomerular filtration in unchanged form, creating high concentrations in the urine.
When applied topically, streptocide creates high local concentrations. Systemic absorption through the damaged skin surface can reach 10%. Excreted mainly in the urine unchanged.
Indication
Treatment of cows with postpartum intrauterine infections (endometritis), to prevent the development of infections with delayed litter, calving with complications and injuries of the birth canal caused by microorganisms sensitive to the active substances of the drug.
Used as a powder for castration of bulls, postoperative complications, wounds, trophic ulcers, cuts.
Contraindication
Do not prescribe to animals with hypersensitivity to the active substances of the drug, impaired liver and kidney function, during pregnancy.
Storage conditions
In a dry, dark place at a temperature of +4 to +20 ° C.
Expiration date
2 years.
Method of application and dosage
In obstetrics and gynecology, a vial of the drug (6 g) is injected into the uterus immediately after removal of manure or abnormal births, during which the birth canal was injured. After 12 hours, the drug is re-administered in the same dose.
In surgical practice, the tool is used externally as a powder for castration, purulent wounds, trophic ulcers, postoperative complications, as well as for the preparation of complex powders used in the treatment of necrobacteriosis and hoof rot.
Reservation
After the last intrauterine administration of the drug slaughter of animals for meat is allowed in 7 days, people can eat milk in 3 days. Meat and milk obtained earlier than this period are disposed of or fed to non-productive animals, depending on the conclusion of the veterinarian.