(solution for injection)

A transparent solution of pale yellow or yellow color.

100 ml of the drug contains the active ingredient:

enrofloxacin – 5 g.

Excipients: potassium hydroxide, benzyl alcohol, highly purified water.

Pharmacological action

Enrofloxacin belongs to the group of fluoroquinolones. The drug inhibits the synthesis of the enzyme DNA gyrase, which is the main factor of DNA catalysis in the nucleus of a microbial cell, as a result of which a rapid bactericidal effect occurs, the degree of which depends on the concentration of enrofloxacin, while the death of bacterial cells sensitive to the drug is observed within 20-30 minutes after his actions. Enrofloxacin is effective both in the latent phase and in the phase of bacterial reproduction.

The drug is effective against gram-negative and gram-positive microorganisms: E. coli , Salmonella spp ., Campylobacter spp ., Haemophilus spp ., Pasteurella spp ., Bordetella spp., Erysipelothrix rhusiopathiae, Klebsiella spp., Staphylococcus aureus, Streptococcus spp. , as well as Mycoplasma spp .

Enrofloxacin is quickly and completely distributed throughout the body from the injection site. In the tissues, it reaches concentrations that are 2-3 times higher than the concentration in the blood. A particularly high concentration of enrofloxacin is observed in the lungs, liver, kidneys, bones and organs of the lymphatic system. The maximum concentration of the drug in the blood is reached after 1.5-2 hours and is maintained for 6 hours, and the therapeutic concentration – for 24 hours. The drug is excreted mainly in unchanged form with urine and bile.

Cattle: treatment of animals suffering from colidiarrhea, cholesepticemia, salmonellosis, staphylococcal infection, mycoplasmosis caused by microorganisms sensitive to enrofloxacin .

Pigs: treatment of animals suffering from pasteurellosis, enzootic pneumonia, bronchopneumonia, colidiarrhea, cholesepticemia, salmonellosis, atrophic rhinitis, MMA syndrome (mastitis, metritis, agalactia) caused by microorganisms sensitive to enrofloxacin .

Dogs: treatment of animals with diseases of the digestive tract, respiratory organs, genitourinary system caused by microorganisms sensitive to enrofloxacin .

Subcutaneously or intramuscularly in doses:

cattle – 1.0 ml of the drug per 20 kg of body weight once a day for 2-3 days;

dogs (subcutaneously) – 1.0 ml of the drug per 10 kg of body weight once a day for 5-10 days.

Intramuscularly in a dose:

pigs – 1.0 ml of the drug per 20 kg of body weight once a day for 2-3 days.

With frequent diseases of the respiratory organs, salmonellosis of cattle and pigs, the dose is doubled (1 ml of the drug per 10 kg of body weight) and administered once a day for 5 days.

*Kilograms to a Pounds conversion table

Kilograms (kg)	Pounds (lb)	Pounds+Ounces (lb+oz)
0.1 kg	0.220 lb	0 lb 3.527 oz
1 kg	2.205 lb	2 lb 3.274 oz
5 kg	11.023 lb	11 lb 0.370 oz
10 kg	22.046 lb	22 lb 0.740 oz

Increased sensitivity to enrofloxacin.

Do not use in animals with insufficient development of cartilage and bone tissue.

Do not use in animals with signs of diseases of the central nervous system.

It is forbidden to use in small breed dogs – in the first 12 months of life, large breeds – in the first 18 months of life, pregnant bitches and sows, as well as bitches during lactation. Do not use on horses.

Do not use simultaneously with tetracycline drugs, macrolides (erythromycin), chloramphenicol, theophylline, nonsteroidal anti-inflammatory drugs.

Do not use for prophylactic purposes, as well as when pathogens resistant to fluoroquinolones are detected.

Slaughter of animals for meat is allowed 12 days after the last administration of the drug. Milk can be consumed 7 days after the last administration of the drug. The meat and milk received by the specified deadline are disposed of or fed to unproductive animals, depending on the opinion of the veterinary medicine doctor.

Glass bottles closed with rubber stoppers under an aluminum break-in of 10, 50 and 100 ml.

Storage

Dry, dark place inaccessible to children at a temperature of 8°C to 25°C.

Shelf life – 3 years.

After the first selection from the bottle, the drug should be used within 14 days, provided it is stored in a dark place at a temperature from ^20° C to 80° ^C .