Spectran (amoxicillin, Betamethasone) Solition for injection, 10 ml

Description

Suspension from white-cream to light yellow.

Composition

1 ml of the preparation contains active ingredients:

• amoxicillin (in the form of amoxicillin trihydrate) – 150.0 mg;
• betamethasone dipropionate (in terms of betamethasone) – 0.5 mg;

Excipients: benzyl alcohol, butylhydroxytoluene, butylhydroxyanisole, aluminum stearate, propylene glycol dicaprylate / dicaprate.

Pharmacological properties

Spectran is a complex drug with a pronounced antimicrobial and anti-inflammatory effect. The active ingredients of Spectran are the antibiotic amoxicillin and the corticosteroid betamethasone; amoxicillin – has a wide range of antimicrobial action, betamethasone – enhances anti-inflammatory processes in the body, prevents the occurrence of possible allergic reactions (including to the components of the drug).

Amoxicillin is a broad bactericidal antibiotic from the aminopenicillin group. It interferes with the synthesis of the cell wall, inhibiting the enzymes transpeptidase and carboxypeptidase, causing a violation of osmotic pressure in the bacterial cell, which leads to the death of bacteria at the stage of their growth. The drug is active against Gram-positive and Gram-negative microorganisms (Streptococcusspp., Pasteurellaspp., Haemophilusspp., Bacillusanthracis, Actinomycesspp., Clostridiumspp., Corynebacteriumspp., Erysipelothrixrhusiopathiae, Listeriamonocytogenes, Actinobacillusspp., Bordetellabronchiseptica, Fusobacteriumspp., Moraxellaspp., Proteusmirabilis, Salmonellaspp.).

The maximum concentration in blood plasma is reached within 1-2 hours after drug administration and remains at a therapeutic level for 48 hours. Amoxicillin is practically not metabolized. It is excreted from the body mainly in the urine, to a lesser extent in milk and bile.

Betamethasone – belongs to the group of synthetic corticosteroids, has anti-inflammatory, anti-allergic, anti-allergic, anti-proliferative effects.

Betamethasone inhibits the function of leukocytes and tissue macrophages. Limits the migration of leukocytes to the area of ​​inflammation. Violates the ability of macrophages to phagocytosis, as well as the formation of interleukin-1. Promotes the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of ​​inflammation. Reduces capillary permeability due to the release of histamine. Suppresses fibroblast activity and collagen formation.

Betamethasone dipropionate has a prolonged effect due to slow absorption. The bioavailability of betamethasone is approximately 72%, the half-life is 5.6 hours, and 64% is bound to plasma proteins. It is metabolized in the liver, excreted by the kidneys, and only a small part is excreted in the bile.

Application

Treatment of cattle and pigs:

in respiratory diseases (bronchitis, bronchopneumonia, rhinitis) caused by microorganisms sensitive to amoxicillin.

Treating dogs and cats:

with diseases of the digestive tract (enteritis, gastroenteritis, gastroenterocolitis), respiratory organs (bronchitis, bronchopneumonia, rhinitis) and the genitourinary system (metritis, endometritis, mastitis, agalactia, cystitis, urethritis, pyelonephritis), joints, skin and soft tissues; acute and chronic otitis media, operating rooms, wound, postpartum and other primary and secondary infections of bacterial etiology caused by microorganisms sensitive to amoxicillin.

Dosage

Intramuscularly or subcutaneously as a single dose

• Cattle, pigs – 1 ml of the drug per 10 kg of animal body weight;
• Dogs, cats – 0.1 ml of the drug per 1 kg of animal body weight.

If necessary, the drug is re-administered after 48 hours.

Contraindications

Do not use in rabbits, guinea pigs, hamsters and other rodents, as well as animals with hypersensitivity to amoxicillin, betamethasone and other components of the drug.

Do not use the drug in cows during the last month of pregnancy; sows, dogs and cats in the first third of pregnancy.

Do not use in weakened, emaciated animals and animals with severe renal failure.

Do not use together with bacteriostatic antibiotics (tetracycline, chloramphenicol, erythromycin, etc.).

Warning

Shake well before use.

Do not inject more than 20 ml into one injection site for cattle, 5 ml for pigs and dogs; 1.0 ml – for cats.

Do not administer intravenously.

Slaughter of animals for meat is allowed 21 days after the last use of the drug. Milk consumption is allowed 3 days after the last injection of the drug. The meat and milk received before the specified time is disposed of or fed to unproductive animals, depending on the conclusion of the veterinary doctor.

Release form

Bottles made of molten glass or polymeric materials, closed with rubber stoppers for aluminum rolling, 10, 50, 100, 150, 200, 250 and 500 ml each.

Storage

A dark place out of the reach of children at a temperature of 5 to 25 ° C.

Shelf life is 2 years.

After the first selection from the bottle – 28 days, provided it is stored in a dry, dark place at a temperature of 5 to 25 ° C.