Synulox RTU, (amoxicillin, calcium clavulanate) Solution for Injection, 100 ml

Composition and form of release

Sinulox RTU is a light cream-colored, sterile oily suspension for injection, containing in 1 ml as active ingredients:

amoxicillin in the form of amoxicillin trihydrate 140 mg

clavulanic acid in the form of calcium clavulanate 35 mg.

Produced in glass bottles of 100 ml.

Pharmacological properties

Sinulox RTU has a wide spectrum of bactericidal activity against most gram-positive and gram-negative microorganisms, including strains producing b-lactamase: Streptococcus spp., Staphylococcus spp., Corynebacterium spp., Clostridium spp., Bacillus anthracstis, Actinomyсherces. coli, Salmonella, Bordetella bronchiseptica, Campilobacter spp., Klebsiella, Proteus spp., Pasteurella, Fusobacterium necrophorum, Bacteroides, Haemophilus spp., Moraxella spp., Actinobacillus pleuropneumoniae and Actinobacillus pleuropneumoniae and Actinobacillus ligneresinobacillus.

Resistance to b-lactam antibacterial drugs is usually due to the ability of microorganisms to produce b-lactamase, an enzyme that destroys the b-lactam ring of an antibiotic before it can act on a bacterial cell.

Clavulanic acid, which is part of Sinulox RTU, inactivates b-lactamase and thereby restores the bacteria’s sensitivity to the bactericidal action of amoxicillin in concentrations that are easily achieved in animal tissues after administration of the drug.

Indications

Prescribed to cattle, pigs, dogs and cats for the treatment of bacterial infections of the respiratory tract, gastrointestinal tract, genitourinary system, soft tissues and skin.

Doses and method of administration

Sinulox RTU suspension for injection is administered to cattle and pigs only intramuscularly, to dogs and cats – intramuscularly or subcutaneously at the rate of 8.75 mg per 1 kg of animal weight, which is equivalent to 1 ml of the drug per 20 kg of animal weight, once a day for 3 – 5 days.

Before each use, the contents of the vial are thoroughly shaken until a homogeneous suspension is obtained.

For the administration of the drug, only dry syringes and needles are used. It is recommended to lightly massage the injection site after the injection of Sinulox RTU.

Side effects

In hypersensitive animals, allergic reactions are possible, which quickly disappear after discontinuation of the drug.

If hypersensitivity reactions occur, it is advisable to administer antihistamines and corticosteroids to animals.

Contraindications

Hypersensitivity to the components of the drug.

It is forbidden to enter intravenously and intratracheally.

Sinulox RTU, like other penicillin antibiotics, is not allowed to be administered to rabbits, guinea pigs, hamsters and gerbils.

The drug should be used with great caution in other small herbivores.

Sinulox RTU suspension for injection must not be mixed with other drugs in the same syringe, nor can it be used simultaneously with bacteriostatic chemotherapeutic drugs.

special instructions

During the treatment period and within 14 days after the last administration of the drug, it is prohibited to slaughter animals for meat.

The meat of animals that were forcedly killed before the expiration of the specified period can be used for feeding fur animals or for the production of meat and bone meal.

Milk can be used for food purposes no earlier than 60 hours after the last use of the drug.

Milk obtained before the expiration of the specified period can be used for feeding animals after heat treatment.

The use of the drug is not indicated for pseudomonous infection.

Storage conditions

With precaution (list B).

Store in a dry place, protected from direct sunlight and out of reach of children, at temperatures from 3 to 25 ºС.

Expiration date:  2 years.

After the first puncture of the plug with a needle, the drug can be used for 28 days.