Сestal plus (pyrantel, praziquantel) Dewormer for Dogs 8 tablets

Description:

Tablets are yellowish-gray in color with a dividing line in the middle.

Compound:

1 tablet of the drug (780 mg) contains active ingredients:

pyrantel embonate – 144 mg,

praziquantel – 50 mg,

fenbendazole – 200 mg.

Excipients: lactose, wheat starch, povidone (K-90), talc, magnesium stearate, dry yeast, flavoring agent, purified water.

Pharmacological properties:

ATCvet QP52A, anti-trematode, anti-nematode and prototype veterinary drugs (ATC-vet QP52AA01 – praziquantel, QP52AF02 – pyrantela embonate, QP52AC13 – fenbendazole.

Cestal plus is a broad-spectrum anthelmintic drug, which contains the active ingredients: praziquantel, pyrantela embonate and fenbendazole, effective against tape and round helminths.

Praziquantel is a pyrazinisoquinolone derivative that is rapidly absorbed through the outer shell of tapeworms, resulting in damage and contraction. The consequence of a violation of the penetrating properties of membranes is paralysis of parasites. Praziquantel is rapidly absorbed in the alimentary canal. Its highest concentration in blood plasma is observed 1-2 hours after administration, it is rapidly metabolized and excreted in the form of metabolites in the urine.

Pyrantela embonate, a tetrahydropyrimidine derivative, acts as a cholinergic antagonist, causing spastic paralysis of round helminths by depolarizing neuromuscular blockade. The maximum concentration of pyrantel embonate in blood plasma is observed after 2-4 hours. Pyrantel embonate is excreted from the body with feces and urine within 24 hours.

Fenbendazole belongs to the benzimidazole group; soluble in formic acid. The mechanism of action of fenbendazole is in violation of glucose transport, disorder of microtubular function and a decrease in the activity of fumarate reductase synthesis in the body of helminths; this action causes paralysis and leads to the death of helminths. Inhibition of the synthesis of fumarate reductase leads to a decrease in the level of glycogen in the body of parasites. Fenbendazole inhibits the polymerization of tubulin in microtubulin, as a result of which the intracellular transport of nutrients and metabolic substances (adenosine triphosphoric acid and glucose) is impaired.

Application:

Deworming of dogs with nematodes and cestodes: Toxocara canis, Toxascaris leonina; Ancylostoma caninum, Uncinaria stenocephala; Taenia species, Dipylidium caninum, Echinococcus species; Trichuris vulpis.

Dosage:

Orally at a dose of 1 tablet per 10 kg of body weight (equivalent to praziquantel 5 mg / kg, pyrantel embonate 14.4 mg / kg, fenbendazole 20 mg / kg).

Puppies and small dog breeds:

less than 2 kg bw ¼ pills

2-5 kg ​​bw 1/2 tablet

5-10 kg bw 1 tablet

Medium breed dogs:

10-20 kg bw 2 tablets

20-30 kg bw 3 tablets

Large breed dogs:

30-40 kg bw 4 tablets

40-50 kg bw 5 tablets

The tablets are fed to animals forcibly or with feed (with a piece of meat, sausage, etc.). You do not need to follow a pre-hunger diet.

For prophylaxis, the drug should be used every three months at a time.

For treatment, the drug is prescribed once. In case of severe infestation, the treatment must be repeated after 14 days.

*Kilograms to Pounds conversion table

Contraindications:

Do not use in animals with hypersensitivity to the components of the drug, in weakened and sick animals.

Caveats:

Not installed.

Storage:

Store in a dry, dark place at temperatures from +15 to + 25 ° C.

Keep out of reach of children and animals, separate from food and feed.

Expiration date : 2 years.