Combined anthelmintic drug. The combination of the active substances included in the preparation provides a wide spectrum of anthelmintic action for all phases of development of round and tapeworms parasitizing in dogs and cats, incl. Toxocara canis, Toxocara cati, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, Trichuris vulpis, Echinococcus granulosus, Echinococcus multilocularis, Diphyllobothrium latum, Dipylidium caninum, Dissimilar spp. …

The mechanism of action of pyrantel pamoate is to block neuromuscular transmission, impair the permeability of cell membranes and inhibition of cholinesterase, which leads to paralysis and death of the parasite. The maximum concentration of pyrantel pamoate in the blood plasma is observed after 2-4 hours. Pyrantel pamoate is excreted from the body with feces and urine within 24 hours.

The mechanism of action of praziquantel is  based on impaired glucose transport and microtubular function in cestodes, inhibition of fumarate reductase activity and ATP synthesis, increased permeability of cell membranes and impaired muscle innervation. Praziquantel is rapidly absorbed from the gastrointestinal tract, its maximum plasma concentration is reached after 30-60 minutes. It is excreted from the body mainly in the urine within 24 hours.

The mechanism of action of the ivermectin, which is part of the drug,   is its effect on the magnitude of the current of chlorine ions through the membranes of the nerve and muscle cells of the parasite. The main targets are glutamate-sensitive chlorine channels, as well as gamma-aminobutyric acid receptors. A change in the current of chlorine ions disrupts the conduction of nerve impulses, which leads to paralysis and death of the parasite. The maximum concentration of ivermectin in blood plasma is observed 9 hours after oral administration. Ivermectin is excreted from the body mainly with bile, feces and partly with urine.

The drug Dironet ^®  tablets, according to the degree of impact on the body, belongs to low-hazard substances, in recommended doses it is well tolerated by animals, does not have embryotoxic, teratogenic and hepatotoxic effects.

Indications for use:
Aromatic flavor additive in the composition of the preparation: the taste of fresh meat for dogs.

Assign to dogs:

– for the treatment and prevention of gastrointestinal nematodes;

– for the treatment and prevention of cestodosis;

– for the prevention of dirofilariasis.

Application procedure

For cestodoses and nematodes of the gastrointestinal tract,  Dironet ^®  tablets with therapeutic and prophylactic purposes are administered individually orally once in the morning feeding at a dose of 1 tablet per 10 kg of animal weight .

For prophylactic purposes, deworming is carried out quarterly, as well as before each vaccination.

To reduce the number of circulating microfilariae  in animals infected with Dirofilaria immitis or Dirofilaria repens, the drug is prescribed once, once a month.

In order to prevent dirofilariasis  in a diseased region, Dironet ^®  tablets are used in the spring-summer-autumn period: once before the beginning of summer mosquitoes (March-April), then monthly from April to October, and the last time in the season – 1 month after the end summer mosquitoes (October-November).

A special diet and the use of laxatives before deworming are not required.

The peculiarities of the action of the drug during its first use or cancellation have not been identified.

Violations of the recommended timing for deworming animals should be avoided, as this can lead to a decrease in effectiveness.

Side effects

As a rule, side effects and complications when using the drug Dironet ^® tablets in accordance with the instructions are not observed.

With increased individual sensitivity of the animal to the active components of the drug and the appearance of allergic reactions, its use is stopped and the animal is prescribed antihistamines and symptomatic therapy.

In case of an overdose of the drug, the animal may experience a depression, refusal to feed, excessive salivation, and gastrointestinal upset. In these cases, enterosorbents and symptomatic therapy agents are used.

Contraindications to the use of the drug DIRONET ^®  TABLETS

– individual hypersensitivity of the animal to the components of the drug.

The use of the drug is not allowed

– puppies and kittens under 3 weeks of age;

– pregnant and lactating animals.

For puppies of the bobtail, collie and sheltie breeds, due to the increased sensitivity of these breeds to macrocyclic lactones, the drug should be used under the supervision of the attending veterinarian.

Special instructions and measures for personal prevention

Dironet ^®  tablets should not be used in conjunction with piperazine and cholinesterase inhibiting drugs.

Dironet ^®  tablets are not intended for use in productive animals.

Personal prevention measures

When working with Dironet ^®  tablets, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines. Do not smoke, drink or eat while working. At the end of work, hands should be washed with warm water and soap.

People with hypersensitivity to the components of the drug should avoid direct contact with the drug

Terms and conditions of storage

The drug should be stored in the manufacturer’s sealed packaging, separately from food and feed, protected from light and moisture, out of the reach of children at temperatures from 0 ° to 25 ° C.

Shelf life is 2 years.