Composition and form of release:

Frontline Combo is a medicinal insecticide-acaricidal preparation in the form of a solution for external use. Frontline Combo contains fipronil – 9.8% and S-methoprene – 8.8% as active ingredients, and polyvidone and polysorbate as auxiliary substances.

Frontline Combo is a colorless transparent liquid with a slight specific odor.

Frontline Combo is produced in packs of 0.5; 0.67; 1.34; 2.68 and 4.02 ml into polyethylene pipettes with snap-off tip

Pharmachologic effect:

Frontline Combo has a pronounced contact insectoacaricidal effect, is active against the preimaginal and imaginal phases of development of lice, fleas, lice and ticks (ixodid, cheilitella) parasitizing on dogs and cats.

The mechanism of action of fipronil, which is part of Frontline Combo, is to block GABA-dependent (GABA (gamma-aminobutyric acid) receptors of parasites, impairing the transmission of nerve impulses, which leads to paralysis and death of ectoparasites).

S-methoprene inhibits the juvenile hormone that promotes the formation of chitin, thereby disrupting the development of fleas at the egg and larval stage.

When applied to the skin, the drug is not absorbed, but gradually, within 24 hours, being distributed over the surface of the body and, being reserved in the sebaceous glands, has a long-term insectoacaricidal effect in the places of localization of ectoparasites.

Frontline Combo, in terms of the degree of impact on the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007.76), in recommended doses, it does not have a skin-resorptive, sensitizing, embryotoxic, teratogenic and mutagenic effect. Causes minor irritation in eye contact.

Indications:

Frontline Combo is used to combat fleas, lice, lice and ticks (ixodid, cheilitella) of dogs and cats.

Doses and method of administration:

The drug is used by topical (point) application of the drug to the skin. Before processing, the tip of the pipette is broken off, the animal’s hair is pushed apart in the region of the back (between the shoulder blades) and, pressing the pipette, the preparation is applied to the skin at one or several points.

Depending on the type and weight of the animal, Frontline Combo pipettes of various volumes are used:

In case of severe damage to the animal by lice, fleas, lice, it is recommended to process it once a month. If the animal is washed more than 2 times a month, it is recommended to reduce the interval between treatments to 3 weeks.

Side effects:

When used correctly, the drug is not observed. With increased individual sensitivity to the components of the drug and the appearance of signs of allergic reactions, the treatment is stopped, the drug is washed off with water, and antihistamines are given inside.

Contraindications:

Sick and recovering animals, as well as puppies and kittens under 8 weeks of age, cannot be processed.

Special instructions:

When working with the drug, you should follow the rules of personal hygiene and safety measures provided for working with veterinary medicinal products. While working with the medicinal product, it is not allowed to drink, smoke, or eat.

In case of accidental contact with Front Line Combo on the skin or mucous membranes, it should be washed off with a stream of water. At the end of work, hands should be washed with warm water and soap.

It is forbidden to use empty pipettes from under the drug for domestic purposes, they must be disposed of with household waste.

It is not recommended to wash animals within 48 hours after treatment with Frontline Combo, as well as to use other insecticidal acaricides.

Storage conditions:

Store the drug in its original packaging, in a dry, dark place, out of reach of children and animals, separately from food and feed, at a temperature of 0 to 35 ° C.

Shelf life:

3 years from the date of manufacture.