Hepatolic Suspension, 100 ml

Suspension from light brown to dark brown with a specific odor of the components.

Storage
1 ml of the drug contains active substances:

essential phospholipids – 60 mg,

methionine – 100 mg,

L-ornithine – 50 mg,

milk thistle extract – 15 mg,

herb immortelle extract – 15 mg.

Excipients: potassium sorbate, sodium benzoate, xanthan gum, twin-80, propylene glycol, distilled water.

Pharmacological properties
ATCvet code QA05BA. Complex functional feed additive for dogs and cats with liver disease.

Hepatolic contains specific nutraceutical components that have membrane-stabilizing, hepatoprotective, antioxidant properties. The complex of components of biologically active substances improves the functional state of the liver and its detoxification function, helps to preserve and restore the structure of hepatocytes, normalizes the level of ammonia in animals, accelerates the regeneration of liver cells.

The main component of the feed additive are the so-called essential phospholipids (EPL-substance), which are a highly purified fraction of phosphatidylcholine. The determining component of this fraction is dilinoleoylphosphatidylcholine. Essential phospholipids are chemically similar to endogenous membrane phospholipids, outperforming them in their functional properties due to their high content of polyunsaturated fatty acids, especially linoleic acid. Phospholipids are the main structural elements of cell membranes and organelles. They are involved in cell differentiation, division and regeneration. The functional significance of phospholipids is based on their amphiphilic properties, which allow to regulate the permeability of the cell membrane. They improve the function of membranes, in particular ion exchange, the process of intracellular respiration, biological oxidation, affect the binding of enzymes of intracellular respiration in mitochondria, as well as the process of oxidative phosphorylation in the energy metabolism of cells. Under physiological conditions, the synthesis of phospholipids meets the normal needs of hepatocytes, which contain a sufficient amount of phospholipids. It is known that the structure of cell membranes and the function of enzyme systems in liver disease are disrupted. The biosynthesis of phospholipids is disturbed, the deficiency of which leads to dysfunction of the cell membrane. These processes are particularly pronounced in mitochondria, which are approximately 30% composed of phospholipids and in which the most important metabolic processes, including oxidative phosphorylation. With a deficiency of phospholipids there is a violation of fat metabolism, which leads to fatty degeneration of the liver. Due to its pharmacological properties, Hepatolyk eliminates these disorders, promotes the regeneration of cell membranes, reactivates damaged membrane-enzyme systems and receptors, increases the detoxification ability of the liver and thus normalizes its function.

Silymarin has a hepatoprotective effect due to competitive interaction with receptors for the corresponding toxins in the hepatocyte membrane, thus showing a membrane-stabilizing effect, stimulates the synthesis of proteins (structural and functional) and phospholipids in damaged hepatocytes, thus accelerating. The action of flavonoids, which include silymarin, is also due to their antioxidant properties and effects that improve microcirculation.

Immortelle extract improves the overall functional state of the liver, enhances the formation of bile and bile acids, improves bile flow through the bile ducts, enhances the secretory and motor functions of the gastrointestinal tract. It is widely used in various diseases of the liver, gallbladder and biliary tract: gallstone disease, biliary dyskinesia, chronic cholecystitis, chronic hepatitis. Immortelle extract has a pronounced antispasmodic effect on the bile ducts and gallbladder sphincter, which in combination with a mild tonic effect on the gallbladder leads to improved bile flow, full release of the gallbladder, cessation of dyskinesia of the biliary tract. The presence of resin acids in immortelle extract provides antiparasitic action against Giardia.

Biologically active substances of immortelle have a complex effect on the hepatobiliary area, significantly enhance the drainage function of the liver, ensuring the reliable elimination of metabolic products and toxins from the bile.

Hepatolic according to the degree of impact on the body is a low-risk substance (hazard class 4 according to GOST 12.1.007-76), in therapeutic doses does not have embryotoxic, teratogenic, carcinogenic and sensitizing effects.

Application
Hepatolic is prescribed to dogs and cats alone or as part of complex therapy for acute and chronic liver diseases of various etiologies, to normalize liver function and regeneration after endo and exotoxicosis, somatic and infectious diseases, as well as to reduce the adverse effects of drugs with hepatotoxicity.

Dosage
The drug is used in dogs and cats orally, individually