COMPOSITION AND FORM OF ISSUE
Trocoxil is a non-steroidal anti-inflammatory drug in the form of tablets for oral administration, containing as an active agent mavacoxib – 20 mg per tablet, and as auxiliary substances, confectionery sugar, microcrystalline cellulose, croscarmellose sodium, sodium laurel sulfate, magnesium stearate and flavor with meat flavor. In appearance, Trocoxil is a triangular light brown tablet with embossed inscriptions: “Pfizer” on one side and the concentration of mavacoxib in the tablet on the other side. The drug is packed in blisters of 2 tablets, which are placed in cardboard boxes.
PHARMACOLOGICAL PROPERTIES
Trocoxil belongs to the group of non-steroidal anti-inflammatory drugs, and has anti-inflammatory, analgesic and antipyretic effects. Mavacoxib, the active ingredient in Trocoxil, blocks the synthesis of inflammatory prostaglandins that cause inflammation, swelling and pain. At therapeutic doses, Mavacoxib has a significantly weaker effect on cyclooxygenase-I, and therefore does not affect the synthesis of protective prostaglandins. Thus, Mavacoxib does not interfere with normal physiological processes in tissues, especially in the stomach, intestines, kidneys and platelets.
Trocoxil is rapidly absorbed from the gastrointestinal tract, reaches a therapeutic concentration 1 hour after administration, and the peak concentration in blood plasma – 17 hours after administration. The half-life in dogs is approximately 39 days. Mavacoxib is more than 98% bound to plasma proteins, and is excreted unchanged mainly in the bile.
INDICATIONS FOR USE
It is used in dogs to treat inflammation and relieve pain in acute and chronic diseases of the musculoskeletal system, with manifestations of arthitis, osteochondrosis, rheumatism, pain in muscles and ligaments, as well as to reduce postoperative pain and edema.
DOSAGE AND APPLICATION
Trocoxil is administered to dogs, starting from 12 months of age, orally at a dose of 2 mg of mavacoxib per 1 kg of animal weight before or during a meal. The drug is reapplied 2 weeks after the first dose, and then with an interval of 1 month. The course of treatment with Trokoksil should not exceed 7 doses of the drug, that is, 6.5 months.
Using the table, you can calculate the number and dosage of tablets according to the weight of the animal:
CONTRAINDICATIONS
Contraindications to the use of Trokoksil are: the age of the animal up to 12 months and / or body weight less than 3 kg; hypersensitivity of the animal to the components of the drug; peptic ulcer of the gastrointestinal tract, severe renal failure.
The drug is prescribed with caution to pregnant animals and during lactation.
STORAGE CONDITIONS
In the sealed manufacturer’s packaging, in a dry, dark place and out of reach of children, separately from food and feed at temperatures from 0 0 C to 30 0 C. The shelf life of the medicinal product, subject to storage conditions, is 3 years.
It is forbidden to use Trokoksil after the expiration date.