Aniprazole (praziquantel, fenbendazole) DEWORMER tablets for dogs and cats

Description

Round corrugated tablet of pale yellow color. The tablet can be divided into equal halves and quarters.

Storage

1 tablet contains the active substance:

• praziquantel – 50.0 mg;
• fenbendazole – 500.0 mg.

Excipients: sodium dodecyl sulfate, povidone K25, magnesium stearate, closcarmellose sodium.

Pharmacological properties

ATCvet classification code QP52A – anthelmintics. QP52AA51- praziquantel, combinations.

The optimal ratio of the two active substances provides the widest range of action of the anthelmintic drug. The drug is highly effective against nematodes of the gastrointestinal tract and lungs. Effective against imaginal and larval stages of parasites.

Praziquantel is a synthetic quinoline derivative. Its mechanism of action is due to impaired permeability of helminth cell membranes to calcium ions, which leads to rapid paralysis of parasites and the destruction of their cell membranes, as well as inhibition of glucose metabolism. This causes the death of parasites and their removal from the gastrointestinal tract. Praziquantel is well absorbed in the gastrointestinal tract and reaches its maximum plasma concentration in 1-2 hours. Praziquantel is rapidly distributed to all organs. The half-life of praziquantel and its metabolites varies in dogs and cats from 2 to 3 hours. Its bioavailability is about 84%. Distributed in the organs and tissues of the animal and binds to blood proteins (70-80%). Metabolized in the liver with the formation of inactive metabolites. Excreted in the urine and in small quantities in the feces. The half-life lasts 48 hours.

Fenbendazole – inhibits the polymerization of tubulin proteins into microtubules, reduces the activity of energy enzymes, which causes the death of parasites from depletion. Shows high anthelmintic activity and a wide range of action against mature and immature stages of parasites. After oral administration, fenbendazole is partially absorbed, metabolized in the liver to sulfoxide (oxfendazole) and then to sulfone (oxfendazole sulfone). Fenbendazole and its metabolites spread to organs and tissues, reaching the highest concentration in the liver of the animal. Excretion occurs mainly in the feces, to a lesser extent – in the urine. The plasma half-life is about 7 hours in cats and 12 to 18 hours in dogs. Excretion of unchanged and metabolised fenbendazole (> 90%) in faeces, slightly in urine and milk.

Application

Prevention and treatment of mixed invasions of dogs and cats from three weeks of age with nematodes: Toxocara cants, Toxascaris leonina, Uncinaria stenocephala, Ancyiostoma caninum, Trichuris vulpis, cestodes: Dipylidium caninun, Taenia spp., Echinocococus, Echinocococus, Echinocococus.

Dosage

The recommended dose is 5 mg praziquantel and 50 mg fenbendazole per 1 kg body weight.

One tablet per 10 kg of body weight.

1 kilogram (kg) is equal to 2.20462262185 pounds (lbs).

1 kg = 2.20462262185 lb

Recommended doses for dogs:

• up to 10 kg – 1 tablet;
• from 10 to 20 kg – 2 tablets;
• from 20 to 30 kg – 3 tablets.

1 kilogram (kg) is equal to 2.20462262185 pounds (lbs).

1 kg = 2.20462262185 lb

Recommended doses for cats:

• up to 4 kg – 1/2 tablet per animal;
• from 8 to 12 kg – 1 tablet.

The tablets are fed to animals forcibly or with food. No pre-starvation diet or special feeding regimen is required.

At medical deworming it is necessary to use Aniprazole tablets three times (once a day) for 3 days in a row.

In prophylactic deworming of animals, Aniprazole tablets are usually used once a quarter (once every 3 months) in the above doses, as well as 2 weeks before vaccination.

Contraindication

Do not use in sick, exhausted or weakened animals.

Do not use in puppies and kittens under 3 weeks of age.

Do not use in pregnant bitches under 39 days.

Do not use in pregnant cats.

Do not use in animals hypersensitive to the active substances.

Do not use in animals with impaired renal or hepatic function.

Reservation

When working with the drug it is necessary to follow the basic rules of hygiene and safety adopted when working with veterinary drugs.

Release form

Blister packs of 30, 60, 120, 240 or 720 tablets, packed in cardboard boxes.

Plastic boxes with 30, 60 or 120 tablets.

Storage

Store the drug in the manufacturer’s packaging and out of reach of children at a temperature not exceeding 30 ºC.

Shelf life 4 years.

For use in veterinary medicine!