Cobactan (cefkinoma) Solution For Injection 2.5%
General information
Trade name of the medicinal product for veterinary use: Cobactan® 2.5% (Cobactan® 2.5%). International non-proprietary name: cefkin.
Dosage form
Suspension for injection.
Composition
Cobactan® 2.5% in 1 ml of suspension contains 29.64 mg of cefkinoma sulfate (equivalent to 25 mg of cefkinoma) and an excipient ethyl oleate as an active ingredient.
Pharmacological properties
Cobactan® 2.5% belongs to antibacterial drugs of the cephalosporin group.
Cefkinoma sulfate, which is part of the drug – the fourth generation cephalosporin, has a broad spectrum of antibacterial action against most gram-positive and gram-negative bacteria, including Escherichia coli, Citrobacter spp., Klebsiella spp., Mannheimia haemolytica, Pasteurella multocida, Protemonella spp. spp., Serratia marcescens, Histophilus somni, Arcanobacterium pyogenes, Bacillus spp., Corynebacterium spp., Staphylococcus spp., Streptococcus spp., Bacteroides spp., Clostridium spp., Fusobacterium spp. rhusiopathiae, including strains producing β-lactamase.
The mechanism of the antibiotic bactericidal action is to inhibit the synthesis of the bacterial cell wall. After parenteral administration of the drug, cefkin enters the systemic circulation, reaching a maximum serum concentration in cattle after 90-120 minutes, in pigs after 15-60 minutes and remains at a therapeutic level for 24 hours. Cefkin binds to serum proteins less than 5%, is relatively quickly excreted from the body (half-life in cattle – 2.5 hours, in pigs – 9 hours), mainly unchanged in the urine.
Cobactan® 2.5% according to the degree of impact on the body belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007).
Application
The drug Cobactan® 2.5% is intended for the treatment of diseases of bacterial etiology in cattle and pigs. Cobactan® 2.5% is prescribed to cattle for the treatment of respiratory diseases caused by Pasteurella multocida and Mannheimia haemolytica, interdigital dermatitis of bacterial etiology, necrobacteriosis and acute mastitis, including those caused by E. coli, and escherichiosis (colibacillosis) of calves; pigs – for respiratory diseases caused by Pasteurella multocida, Haemophillus parasuis, ActinobaciUus pleuropneumaniae, MMA syndrome (mastitis-metritis-agalactia), meningitis caused by Streptococcus spp, arthritis, dermatitis and other infections of bacterial etiology caused by susceptible kephi.
Dosage
The drug Cobactan® 2.5% is allowed to be used by animals during pregnancy and lactation.
Cobactan 2.5% is administered to animals deeply intramuscularly once a day for 2-5 days, at the doses indicated in the table:
Kind of animal | Indications | Daily dose of cefkinoma / Kobactan 2.5% | Application scheme |
Cattle | Respiratory Diseases | 1 mg of cefkinoma per 1 kg of animal weight (2 ml of the drug per 50 kg of animal weight) | Once a day for 3-5 days |
Acute interdigital necrobacteriosis, dermatitis of bacterial etiology in the area of the fingers | 1 mg of cefkinoma per 1 kg of animal weight (2 ml of the drug per 50 kg of animal weight) | ||
Acute mastitis complicated by septicemia | 1 mg of cefkinoma per 1 kg of animal weight (2 ml of the drug per 50 kg of animal weight) | Once a day for 2 days | |
Escherichiosis of calves (colibacillosis) | 2 mg of cefkinoma per 1 kg of animal weight (4 ml of the drug per 50 kg of animal weight) | Once a day for 3-5 days | |
Pigs | Respiratory Diseases | 2 mg of cefkinoma per 1 kg of animal weight (2 ml of the drug per 25 kg of animal weight) | Once a day for 3 days |
MMA Syndrome | 2 mg of cefkinoma per 1 kg of animal weight (2 ml of the drug per 25 kg of animal weight) | Once a day for 2 days | |
Meningitis | 2 mg of cefkinoma per 1 kg of animal weight (2 ml of the drug per 25 kg of animal weight) | Once a day for 5 days | |
Arthritis | 2 mg of cefkinoma per 1 kg of animal weight (2 ml of the drug per 25 kg of animal weight) | Once a day for 5 days | |
Dermatitis | 2 mg of cefkinoma per 1 kg of animal weight (2 ml of the drug per 25 kg of animal weight) | Once a day for 5 days |
Shake the bottle with the drug thoroughly before each use.
To prevent a local reaction during the treatment of the animal, it is recommended to change the injection sites of the drug.
Contraindications for use
Increased individual sensitivity of the animal to the components of the drug, as well as to others (3-lactam antibiotics).
Caveats
When working with Cobactan® 2.5%, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines.
People with hypersensitivity to the components of the drug should avoid direct contact with Cobactan® 2.5%. When working with a medicinal product, it is prohibited to drink, smoke and eat; after work, wash your hands with warm water and soap.
It is forbidden to use empty vials from under the medicinal product for household purposes, they must be disposed of with household waste.
In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. In the event of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (you should have instructions for use of the drug or a label with you).
Side effects
As a rule, there are no side effects and complications when using Cobactan® 2.5% in accordance with this instruction. In some animals, a local reaction in the form of edema is possible at the injection site, which can persist for 10-15 days. These symptoms go away on their own and do not require medication. In case of increased individual sensitivity of the animal to the components of the drug or other (3-lactam antibiotics) and the manifestation of allergic reactions, the use of the drug is discontinued, and the animal is prescribed antihistamines and symptomatic therapy.
Overdose
Overdose symptoms when using the drug in accordance with this instruction has not been established.
special instructions
Cobactan® 2.5% should not be used simultaneously with bacteriostatic drugs due to a decrease in its bactericidal activity.
The features of the action of the drug during its first use and cancellation have not been identified.
Skipping the administration of the next dose of the drug should be avoided, as this can lead to a decrease in therapeutic efficacy. If you miss the introduction of one or more doses of the drug, you should enter it as soon as possible in the prescribed dosage and according to the same treatment regimen.
Slaughter of cattle for meat is allowed no earlier than 8 days, pigs – no earlier than 4 days after the last application of Cobactan® 2.5%. The meat of animals that were forcedly killed before the expiration of the specified periods can be used as feed for fur animals. Milk of dairy cows during the treatment period and the next 3 days after the last application of Cobactan® 2.5% must not be used for food purposes. Such milk can be used after heat treatment to feed carnivores.
Package
Cobactan® 2.5% is produced packaged in 100 ml bottles in glass bottles of appropriate capacity, hermetically sealed with rubber stoppers, reinforced with aluminum caps with clips for first opening control. Vials are packed in individual cardboard boxes along with instructions for use.
Storage
Cobactan® 2.5% is stored and transported in a place protected from direct sunlight, at a temperature of 2 to 25 ° C. Cobactan® 2.5% should be kept out of the reach of children.
During storage, the formation of a precipitate is possible, which disappears when shaken.
The shelf life of the medicinal product, subject to the storage and transportation conditions in the manufacturer’s sealed packaging, is 2 years from the date of production, after the first opening of the bottle – 4 weeks.
It is forbidden to use Cobactan® 2.5% after the expiration date.
Unused medicinal product is disposed of in accordance with legal requirements.