Estrofan, 10 x 2 ml (cloprostenol)
Storage:
1 ml of the drug contains the active substance:
cloprostenol (in the form of sodium salt) – 0.25 mg
Excipients: citric acid, sodium hydroxide, chlorocresol, water for injections.
Pharmacological properties:
Cloprostenol is a synthetic functional analogue of prostaglandin F2α, which is characterized by a specific luteolytic action. Its use in the luteal phase of the sexual cycle causes the disappearance of the corpus luteum and creates the preconditions for the onset of ovulation and heat within 48-96 hours after administration. Compared with natural prostaglandin F2α, the luteolytic effect of cloprostenol is 200-400 times higher.
Application:
Cattle: synchronization and stimulation of heifers in heifers and cows.
Sows: induction of farrowing.
Mares: abortion in the first half of normal and pathological pregnancy.
Therapy.
Cattle: functional ovarian disorders, postpartum and postservice anestrus, chronic endometritis, pyometra. Stimulation of childbirth. Interruption in the first half of normal and pathological pregnancy. Combination therapy of follicular cysts (from the tenth day after administration, after the establishment of a positive ovarian response).
Mares: “quiet” hunting, persistent diestrus, embryonic miscarriages, lactation anestrus, abortion of pseudopregnancy. Interruption in the first half of normal and pathological pregnancy.
Dosage:
The drug is administered by intramuscular injection.
Cattle:
heat synchronization: enter 2 ml of the drug (0.5 mg of active substance) in any phase of the sexual cycle (for cows for 40-60 days after calving). On the 11th day after the first application, the second dose is administered, and on the 14th day (72-76 hours after the second dose), artificial insemination is performed, despite the external signs of heat, followed by re-fertilization on the 15th day;
functional disorders of the ovaries: after the introduction of 2 ml of the drug (0.5 mg of active substance) conduct artificial insemination during the first heat. If the heat does not occur, the drug is re-administered in a dose of 2 ml on the 11th day after the first application, followed by artificial insemination after 72-76 hours, if necessary, re-fertilization. For the treatment of follicular cysts, 2 ml of the drug is administered once, but not earlier than 10 days after the introduction of hCG or LHRH with a positive ovarian response. Heat will begin on the 3rd day after drug administration;
postpartum diseases of the uterus: enter 2 ml of the drug, if necessary, treatment can be supplemented by intrauterine use of foaming agents. On the 11th day the drug is re-administered, on the 14th day artificial insemination is performed, and on the 15th day – re-artificial insemination;
for abortion, 2 ml of the drug is administered, further treatment is carried out depending on the clinical condition of the animal.
Sows:
a single dose of 0.7 ml of the drug (0.175 mg of active substance) is administered starting from 111 days of pregnancy. Most induced farrowing occurs within 40 hours after administration, culminating in the range of 24-35 hours.
Mares:
a single dose of 1 ml of the drug (0.25 mg of active substance) is administered for 5-13 days after heat, for 4-6 days after administration, artificial insemination is performed.
Contraindications:
Do not apply to sensitive animals.
Do not use in mares whose meat is intended for human consumption.
Warnings:
Before use, conduct a gynecological examination of animals. The drug is used in animals not below the average level of fattening in farms with a favorable epizootic condition.
Slaughter of animals for meat is allowed 24 hours after the last application of the drug. The meat obtained before this deadline is disposed of or fed to unproductive animals, depending on the opinion of the veterinarian. The period of excretion of the drug from milk is 0 days.
Increased sweating in mares, which disappears within the first hour after administration.
Release form:
Glass ampoules with a capacity of 2 ml. Ampoules with the drug are placed in a cardboard box, 10 ampoules in each box.
Glass vials closed with a rubber stopper under an aluminum run-in of 10 ml. Vials with the drug are placed in a cardboard box, 1 vial in each box.
Storage:
Dry, dark, inaccessible to children at a temperature of 10 ° C to 25 ° C.
Shelf life: 3 years. The drug from an open vial is used for 28 days, provided that it is stored at a temperature of 2 ° C to 8 ° C.
For use in veterinary medicine!