Castran (acepromazine) Solution for injection, 100 ml

Structure

1 ml of the drug contains active ingredient (mg):

acepromazine maleate – 15.0

Excipients: benzyl alcohol, sodium hydroxide, sodium chloride, water for injection

Appointment

Acepromazine maleate is a neuroleptic of the phenothiazine group. The action is aimed at blocking dopaminergic receptors at different levels in the central nervous system. The dopamine neurotransmitter of the central nervous system regulates behavior, locomotor activity, sectoral function and vomiting. Acepromazine acts on the anterior and mesolimbal dopaminergic structures (blocking dopaminergic receptors, which are responsible for the psychotropic properties of the brain, that is, for the behavior of the animal).

In addition, the drug acts hypothermically, hypotensive, antihistamine, adrenolytic and antiemetic. Metabolism of acepromazine occurs in the liver, and the excretion of the drug is carried out by the kidneys. Sedation lasts up to 12 hours.

The drug is used in animals for premedication before surgery to relieve pain in cattle, horses, pigs, dogs and cats; as a sedative for aggressive animals before inspection and transportation.

Dosage

Intravenous, intramuscular in doses:

• cattle, calves, horses, pigs for sedation, slight relaxation, premedication before surgery is used intravenously at 0.5 ml per 100 kg of body weight or intramuscularly at 1.0 ml per 100 kg of body weight for long-term sedation, administered intravenously at 1 , 0 ml per 100 kg of body weight or intramuscularly at 2.0 per 100 kg of animal body weight;
• dogs, cats for sedation, slight relaxation, premedication before surgery, use 0.25 ml per 10 kg of body weight intravenously or intramuscularly; for long-term sedation, 0.5 ml per 10 kg of body weight is used intravenously or intramuscularly.

*Kilograms to Pounds conversion table

Contraindications

Do not use in animals with impaired liver, heart and lung function, diabetes mellitus. Do not use in pregnant animals. Do not use together with organophosphates (insecticides). Do not use in conjunction with local anesthetics. Do not use in cases of hypothermia, hypotension, hypovolemic anemia (anemia due to blood loss), hypovolemic shock. Do not use in case of intoxication with strychnine.

Warning

Stallions are recommended to use the drug only intramuscularly, observing the minimum dose. The drug has no analgesic effect at all; an additional analgesic should be used for pain relief. It is necessary to take into account the hypersensitivity to the drug in dogs of some breeds, namely: Greyhounds, dogs of large breeds, boxers and other representatives of brachycephalic breeds. Intravenously inject slowly. Avoid skin contact with the drug. Increasing the dose does not lead to prolongation.

Side effect

Possible phenomena of bradycardia, narrowing of the airways, a slight decrease in body temperature. With rapid introduction, cardiac arrhythmias may occur.

Withdrawal period

Slaughter of animals for meat is allowed after 5 days, and the consumption of milk for human consumption – 1 day after the last use of the drug. By the specified date, the products are disposed of or fed to unproductive animals, according to the conclusion of a veterinary doctor.

Release form

Vials made of dark glass are closed with a rubber stopper for an aluminum rim of 100 ml.

Storage

The drug is stored in a dry, dark place at a temperature of 15 ° C to 25 ° C.

After the first selection from the vial, the drug must be used within 14 days, under storage conditions in a dark place at a temperature of 2 ° C to 8 ° C.