Prac-Tic (Pyripole/Pyriprol) Flea & Tick Treament for Dogs 22-50 kg – 3 Pipettes

INSTRUCTIONS
for the use of Prac-tic® for the fight against ectoparasites in dogs

(manufacturing organization “Klocke Verpackungs-Service GmbH” /
“Kloske Verpaskung-Service GmbH”, Germany)

I. GENERAL INFORMATION
1. Praс-tic is an insectoacaricidal drug in the form of a solution for external use, designed to combat insects and ixodid ticks parasitizing dogs, as well as to protect animals from their attack.
2. Praс-tic contains pyriprol – 12.5% ​​as an active ingredient and auxiliary components – butylhydroxytoluene and diethyl glycol monoethyl ether.
3. In appearance, the preparation is a colorless or yellow solution.
4. Produce Praс-tiс packaged in 0.45 cm3 (for dogs weighing 2-4.5 kg); 1.1 cm3 (for dogs weighing 4.5-11 kg); 2.2 cm3 (for dogs weighing 11-22 kg) and 5.0 cm3 (for dogs weighing 22-50 kg) in polypropylene pipettes of appropriate capacity, packed in 3 pieces in aluminum foil blisters. Blisters are placed in 1, 2, or 10 pieces in cardboard boxes along with instructions for use.
Each blister and box is marked in Russian with an indication of the manufacturing organization, its address, and trademark, the name, the purpose of the method of application, the volume of the drug in the pipette, the number of pipettes in the package, the name and content of the active ingredient, batch number, date of manufacture, expiration date, storage conditions, the inscription “For animals”, the state registration number and information on the confirmation of conformity.
Store the drug with caution (list B) in a dry, dark place, separate from food and feed, at a temperature not exceeding 300C.
The drug’s shelf life, subject to storage conditions, is 3 years from the date of manufacture.
Prac-tic® after the expiration date should not be used.

II. PHARMACOLOGICAL PROPERTIES
5. Piriprol, which is part of the drug, belongs to the class of phenylpyrazole, has a pronounced insecticidal and acaricidal effect against the imaginal and preimaginal phases of development of insects parasitizing on dogs, including fleas (Stenocephalides canis), lice (Tognatus setotus) canis), as well as ixodid ticks – Ixodes ricinus, Rhipicephalus sanguineus, Dermacentor reticulatus, Ixodes scapularis, Dermacentor variabilis, Amblyomma americanum.

The mechanism of action of pyriprol is based on interaction with chlorine channels, including the neurotransmitter-dependent gamma-aminobutyric acid (GABA), which blocks the pre- and postsynaptic transport of chlorine ions across cell membranes. This leads to a disruption in the transmission of nerve impulses, causing the death of insects and ixodid ticks.
After drip application of the drug to the skin, pyriprol is gradually distributed over the animal’s coat, providing an insectoacaricidal effect.
6. Practitioner® according to the degree of impact on the body refers to moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76), does not have skin irritating and resorptive toxic properties; in recommended doses does not have embryotoxic and teratogenic effects. Well tolerated by dogs of different breeds and ages. The drug is toxic to bees, as well as fish and other aquatic organisms.

III. APPLICATION PROCEDURE
7. Prac-tic® is prescribed for the purpose of eliminating fleas, lice, lice and ixodid ticks parasitizing on dogs, as well as to protect animals from their attack.
8. The drug is applied to animals once by drip (“spot-on”) application to dry intact skin.
Before use, break off the tip of the pipette, then, pushing the fur apart and pressing the pipette, the drug is applied to the animal directly on the skin in places inaccessible for licking – between the shoulder blades at the base of the neck. When processing large animals, the contents of the pipettes are applied to the skin at 2 – 3 points along the back line
9. The minimum therapeutic dose of Prac-tic® is 0.1 ml per 1 kg of animal weight, which is equivalent to 12.5 mg of pyriprol per 1 kg of animal weight. Depending on the weight of the animal, Prak-tik® is used in various packaging in the doses indicated in the table:

 * When treating dogs weighing more than 50 kg, Prak-tik® is used in a dose of 0.1 ml for each kg of animal weight, using a combination of pipettes of different packaging.
10. For the destruction of fleas and ticks, the treatment of dogs is carried out once, to prevent re-infestation throughout the season of activity of parasites – according to indications, but not more often than once a month.
When treating allergic dermatitis caused by insects, it is advisable to use the drug in combination with drugs for pathogenetic and symptomatic therapy.
11. Practitioner® is not allowed to be used by patients with infectious diseases and convalescent animals, as well as dogs weighing less than 2 kg and puppies under 8 weeks of age. Treatment of puppy and lactating bitches must be carried out under the supervision of a veterinarian.
The drug should not be applied to damp or damaged skin, used simultaneously with other insecticidal acaricidal drugs, wash the animal with a detergent within 48 hours before treatment, and wash and bathe within 24 hours after treatment with the drug.
12. When using Prak-Tik® in accordance with this instruction, side effects and complications in animals, as a rule, are not observed. In rare cases, after using the drug in some animals, individual skin reactions (redness, itching) are observed, which spontaneously disappear within 1-4 days and do not require the use of drugs.
In case of an overdose, neurological symptoms are noted: deterioration of coordination, tremor, shortness of breath, hypersalivation (when licking the drug). These symptoms disappear spontaneously within a few hours and do not require the use of drugs.

IV. PERSONAL PREVENTION MEASURES

13. When working with Prak-tik®, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines.
14. While working with the drug, it is not allowed to smoke, drink or eat.
15. At the end of work wash your hands thoroughly with warm water and soap.
16. Do not iron the areas of application of the drug and keep the animal close to small children within 24 hours after treatment with Prak-Tik®.
17. In case of accidental contact of the drug on the skin or eyes, it should be washed off immediately with a stream of water, if swallowed, consult a doctor.
18. It is forbidden to use pipettes from a medicinal product for household purposes. Empty pipettes and packaging are placed in a plastic bag and disposed of with household waste.
19. Prak-tik® should be stored out of the reach of children.