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-32%NewHuvepharma, Bulgaria
Rodotium 10 thiamulin injection
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Home Antibacterial ♦ Antibiotics Rodotium 10% (thiamulin) injection, 100 ml
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Oxytocin 10 UNITS no prescription bf
Oxytocin 10 UNITS Solution for injection BF 300ml (100ml*3pcs) 75.00 € 47.75 €
Huvepharma, Bulgaria

Rodotium 10% (thiamulin) injection, 100 ml

46.99 € 31.89 €

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SKU: Rodotium 10%-100 ml Category: Antibacterial ♦ Antibiotics Tags: thiamulin hydrogen, Tiamulin
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Description

Rodotium 10% (thiamulin) injection, 100 ml

100 ml of the drug contain the active substance:

thiamulin hydrogen fumarate – 10.0 g

Excipients: butyl parahydroxybenzoate, propyl gallate, sesame oil.

PHARMACOLOGY

Tiamulin is a semi-synthetic antibiotic that belongs to the pleuromutilin group. The antibiotic has a bacteriostatic effect, inhibiting protein synthesis in sensitive microorganisms. The drug is active against gram-positive and gram-negative microorganisms (Brachyspira innocens, Brachyspira pilosicoli, Leptospira spp., Clostridium perfringens, Streptococcus spp., Staphyloccocus spp., Erysipelothrix rhusiopathiae, Listeria scytacogelo, Listeria monocytogege pneumoniae, Haemophilus spp., Bacteroides spp., Campylobacter coli, Lawsonia intracellularis), as well as chlamydia and mycoplasma (Mycoplasma hyopneumoniae, M. hyosynoviae, M. hyorhinis, M. bovis and others).

Tiamulin acts at the 70S ribosomal level, the primary binding site is at the 50S sublevel, and the secondary site is possible at the 50S and 30S sublevel junctions. It inhibits the synthesis of proteins by microbes, creating biochemically inactive initiative complexes that inhibit the growth of the polypeptide chain.

Bactericidal concentrations are approximately 50-100 times higher than the bacteriostatic level.

Tiamulin is rapidly absorbed into the blood, is well distributed in the body and is concentrated in the lung tissue after intramuscular injection. Following parenteral administration (doses of 10 and 15 mg / kg bw), the highest serum levels in pigs were detected 2 hours after dosing. After intramuscular injection of tiamulin at a dose of 15 mg / kg m.t. C max  and t max  in serum are 0.77 mg / ml and 2 hours, respectively. Two hours after administration of the therapeutic dose, the concentrations of tiamulin in the pulmonary (15.6 mg / ml) and bronchial epithelium (6.0 mg / ml) were much higher than in blood plasma. The concentration of tiamulin in the lungs, colonic mucosa and colon was 26.9; 2.58 and 3.09 mg / g, respectively.

More than 95% of the therapeutic dose of tiamulin is excreted from pigs in less than a day, and the half-life is less than one day. Tiamulin is well metabolized, approximately 60% of the administered dose is excreted in the bile, about 29% – in the urine.

APPLICATION

Treatment of pigs with dysentery, enzootic pneumonia, pleuropneumonia, arthritis caused by thiamulin-sensitive microorganisms.

DOSAGE

Intramuscularly in doses:

in the treatment of dysentery, enterocolitis and proliferative enteropathy, the dose is – 1.0 ml per 12.5 kg of body weight (in severe cases, the injection can be repeated after 24 hours);

in the treatment of enzootic bronchopneumonia and mycoplasmal arthritis in pigs, the dose is 1.5 ml of the drug per 12.5 kg of body weight once a day for 3 days;

in the treatment of actinobacillary pleuropneumonia in pigs, the dose is 2.0 ml of the drug per 12.5 kg of body weight once a day for 3 days.

*Kilograms to a Pounds conversion table

Kilograms (kg) Pounds (lb) Pounds+Ounces
(lb+oz)
0.1 kg 0.220 lb 0 lb 3.527 oz
1 kg 2.205 lb 2 lb 3.274 oz
5 kg 11.023 lb 11 lb 0.370 oz
10 kg 22.046 lb 22 lb 0.740 oz

CONTRAINDICATION

Hypersensitivity to tiamulin. Do not use products containing monensin, narasin or salinomycin in pigs for at least 7 days before, during and after tiamulin treatment.

Slaughter of animals for meat is allowed 10 days after the last application of the drug. The meat obtained before this deadline is disposed of or fed to unproductive animals, depending on the opinion of the veterinarian.

STORAGE

Dry, dark, inaccessible to children at a temperature of 15 ° C to 25 ° C.

Shelf life – 2 years.

After the first withdrawal from the vial, the drug should be used within 28 days, provided storage in a dark place at a temperature of 10  0 C to 25  0 C.

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