Cyflodex (Ciprofloxacin + Dexamethasone)
1 ml of the drug contains:
ciprofloxacin hydrochloride – 4.5 mg
dexamethasone sodium phosphate – 1 mg
The combined chemotherapeutic agent combines a broad-spectrum antibiotic from the group of fluoroquinolones (ciprofloxacin) and a glucocorticosteroid (dexamethasone), has antibacterial, anti-inflammatory, anti-allergic and desensitizing properties.
Ciprofloxacin acts bactericidal by inhibiting DNA gyrase and inhibiting bacterial DNA synthesis. Active against gram-negative microorganisms during dormancy and division – Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Vibrio spp., Campylobacter spp., Hafnia spp. stuartii, Haemophilus spp., Pasteurella multocida, Pseudomonas spp., Gardnerella spp., Neisseria spp., Moraxella catarrhalis, Acinetobacter spp., Brucella spp. , Listeria monocytogenes and other pathogens – Chlamydia spp., Mycoplasma spp., Mycobacterium spp.
It is well absorbed, after 60 minutes its concentration in the tear fluid is 4.98 μg / ml, and in the fluid of the anterior chamber of the eye – 2.59 μg / ml. The half-life from the anterior chamber of the eye is 2 hours. When instilled into the eyes, the concentration of ciprofloxacin in the blood does not exceed 2.5 ng / ml, when instilled into the ears – the maximum concentration in the blood is observed after 15-90 minutes and is approximately 0.1% of the concentration of ciprofloxacin administered orally at a dose of 250 mg.
Dexamethasone is a synthetic fluorinated glucocorticosteroid with anti-inflammatory, anti-allergic and antiproliferative effects. Reduces capillary permeability and proliferation, local exudation, cellular infiltration, phagocytic activity, collagen deposition and fibroblast activity, inhibits scar tissue formation and inflammation. Anti-inflammatory effect after instillation lasts 4-8 hours. When applied topically, systemic absorption is low. After instillation into the eyes, dexamethasone penetrates well into the corneal epithelium, conjunctival cells and the fluid of the anterior chamber of the eye, its maximum concentration of 30 ng / ml is recorded after 2 hours, the half-life is 3 hours. When applied to the ears, the maximum concentration in the blood is observed after 15-90 minutes and is approximately 14% of the concentration of dexamethasone administered orally at a dose of 5 mg.
Treatment of dogs, cats, small exotic and ornamental animals (ornamental rabbits, hamsters, rats, mice, ants, parrots, reptiles) with acute and chronic inflammation of the eyes and ears, which are the result of bacterial, chemical or traumatic exposure – conjunctivitis , blepharitis, keratitis, keratoconjunctivitis, iriditis, iridocyclitis, corneal ulcers and erosions, eye diseases after injuries, foreign bodies or aggressive compounds in the pre- and postoperative periods, as well as treatment of otitis, otorrhea, including those caused by external interventions.
Method of application and dosage
Before use, the drug is shaken and instilled into the conjunctival sac 1-2 drops 2-4 times a day (in severe cases for 1-2 days instilled 1-2 drops every 2-3 hours) or the ear canal 1-4 drops (depending on the weight of the animal) 2-3 times a day.
In the presence of significant purulent or mucopurulent secretions, preliminary hygienic treatment of the eyes or ears is performed: 3-4 drops are instilled and the secretions are removed with a sterile gauze swab, after which 1-2 drops of the drug are instilled. The course of treatment until complete recovery is 5-10 days.
When instilled into the eyes, local irritation, itching, tearing, which pass quickly, sometimes – allergic reactions, and with prolonged use – the development of secondary glaucoma, steroid cataracts are sometimes possible. Use with caution in animals under 7 days of age and pregnant animals.
Do not prescribe to animals with hypersensitivity to the active substances of the drug.
Do not use in viral and fungal infections of the eyes and ears, simultaneously with nonsteroidal anti-inflammatory drugs, theophylline, amphotericin and other drugs that excrete calcium, and during vaccination.
In a dry, dark place, out of reach of children, at a temperature of +10 to +25 ° C.
After opening the vial, use the drug for 30 days.