Domitor, 10 ml
Composition and form of release
An aqueous solution for injection containing 1 mg of medetomidine hydrochloride as an active ingredient in 1 ml. In appearance, the drug is a clear, colorless solution. Domitor is produced in glass bottles sealed with rubber stoppers with 10 ml aluminum caps.
Indications
Domitor is used for dogs as an immobilizing, sedative and analgesic agent during clinical examination, diagnostic procedures, for premedication before thiopentone and halothane anesthesia. For cats – as an immobilizing and sedative agent. In combination with ketamine – for induction of anesthesia before general anesthesia for surgical operations.
Pharmacological properties
The active substance of the domitor is medetomidine. Medetomidine-a2-agonist, the main effect of which is to inhibit the transmission of nerve impulses in adrenergic synapses due to competition with norepinephrine. Under the action of the drug in animals, depression of the central nervous system and an increase in the pain threshold are observed.
The action of medetomidine is dose-dependent: small doses produce moderate sedation without analgesia, while large doses cause significant sedation and analgesia. Domitor is rapidly absorbed after intramuscular injection, the concentration of the drug in the blood reaches a maximum after 15-30 minutes.
Medetomidine is rapidly distributed in the body. From 85% to 90% of the drug binds to serum proteins. Medetomidine is oxidized in the liver, a small part is methylated in the kidneys. Most of the metabolites of the drug are excreted in the urine. The half-life is 1-2 hours.
Doses and method of administration
Pure domitor is injected intramuscularly, intravenously and subcutaneously in dogs, and intramuscularly and subcutaneously in cats. The maximum effect occurs in 10-15 minutes. The duration of the clinical action depends on the dose and varies considerably (from 30 to 80 minutes). The drug acts faster after intravenous administration, more slowly after intramuscular and subcutaneous administration. The degree of sedation can be regulated by adjusting the dose of the drug.
To maintain a sedative and analgesic effect, the drug can be re-administered 10-15 minutes after the first injection.
To achieve sedation and analgesia, it is used in the following doses:
dogs: 0.1-0.8 ml / 10 kg,
cats: 0.05-0.15 ml / kg.
Doses of the drug vary depending on the desired effect, individual characteristics and the breed of the animal. High doses cause pronounced sedation and analgesia, low doses have only a sedative effect.
Small breed dogs require a higher dose of domitor than large dogs. Insertion of a domitor may cause a decrease in heart rate and respiratory movements.
Side effects
Blood pressure rises immediately after administration of the drug, then drops to normal or remains somewhat reduced. Some dogs and most cats may vomit after 5-10 minutes. after injection, and in a number of cats this is observed at the exit from anesthesia. In some cases, there is a slight twitching of certain muscle groups. Under the influence of the domitor, the heart rate slows down and the body temperature decreases. After using the drug, animals should be kept warm for at least 12 hours.
With oppression of blood circulation and respiration, oxygenation is indicated. Atropine can be used to increase heart rate, but it should be borne in mind that it can cause arrhythmias. The domitor effect can be eliminated by using a specific antagonist – antisedan.
Contraindications
Contraindications for use are: heart failure; impaired liver or kidney function; pregnancy.
Storage conditions
In sealed manufacturer’s packaging, in a dry place, protected from direct sunlight, out of reach of children. Separated from food and feed at a temperature of 15 C to 25 C. The shelf life of the drug, subject to storage conditions in a sealed package, is 3 years from the date of production, after opening the bottle – 28 days. It is prohibited to use Domitor after the expiration date.
