Enroxil 150 mg (enrofloxacin 150 mg) for Dogs, 30 tablets

Description

Barely biconvex, with beveled edges and a notch on one side, cream to pale brownish color with possible white and dark spots.

Composition

1 tablet (550 mg) contains active ingredient:

enrofloxacin – 150 mg.

Excipients: mannitol, corn starch, sodium starch glycolate, meat flavor 10022, acrylate copolymer, sodium lauryl sulfate, dibutyl sebacate, sodium croscarmellose, colloidal silicon dioxide, talc, magnesium stearate.

Pharmacological properties

ATC vet classification code QJ01 – antibacterial veterinary drugs for systemic use. QJ01MA90 – Enrofloxacin.

Enrofloxacin belongs to the antibiotics of the fluoroquinolone group. It is effective against most pathogenic microorganisms: Mycoplasma spp., E. coli, Salmonella spp., Campylobacter spp., Haemophilus spp., Pasteurella spp., Bordetella spp., Erysipelothrix rhusiopathiae, Klebsiella spp., Proteibrio spp., Virus Staphylococcus aureus, Streptococcus spp., Clostridium perfringens, Actinobacillus spp. and enterococci. Enrofloxacin exhibits antimicrobial action by inhibiting the activity of the enzyme DNA gyrase, which is a catalyst for DNA replication in a bacterial cell. Inhibition of DNA gyrase activity leads to functional disorders, blocking of biosynthesis in the cell and death of the pathogenic microorganism. Has a bactericidal effect, especially against microorganisms,

In studies on dogs, when using enrofloxacin at a dose of 4.91 mg / kg body weight, the maximum plasma concentration of 1179.94 ± 260.83 ng / ml was achieved after 1.57 ± 0.62 hours. The half-life is 3.78 hours.

Almost 40% of enrofloxacin given orally to dogs is converted to ciprofloxacin. The maximum plasma concentration of ciprofloxacin reaches 491.99 ± 57.95 ng / mg. Tmax is 1.79 ± 2.6 hours. The half-life is 5.10 hours.

Enrofloxacin is rapidly absorbed into tissues. The concentration in tissues and tissue fluids is 2-3 times higher than the concentration in blood serum. High levels of enrofloxacin are found in the lungs, liver, kidneys, skin, bones, and lymphatic system. Enrofloxacin also enters the CSF, intraocular fluid, and the fetus of pregnant animals.

Enrofloxacin is excreted mainly in the urine.

Application

Treatment of dogs with diseases of the digestive tract, respiratory and genitourinary system, skin and ears (otitis externa), secondary infections of wounds caused by microorganisms sensitive to enrofloxacin.

Dosage

Orally at a dose of 5 mg of enrofloxacin per 1 kg of body weight (1 tablet per 30 kg of body weight) once a day or 2.5 mg (1/2 tablet per 30 kg of body weight) twice a day, regardless of feeding.

The duration of treatment is 5-10 days.

Contraindications

Hypersensitivity to enrofloxacin.

Do not use when detecting resistant strains of pathogenic bacteria resistant to quinolones.

Do not use in small breeds in the first 12 months of life and in large breeds in the first 18 months of life.

Do not use on animals with signs of diseases of the central nervous system.

Do not use simultaneously with tetracycline drugs, macrolides, chloramphenicol, theophylline.

Do not use Enrofloxacin prophylactically.

Warning

Quinolone drugs cause damage to the cartilage of the joints caused by weight gain and other forms of arthropathy in young animals that are growing rapidly. Use with caution in dogs with severe renal and hepatic impairment.

Release form

10 tablets in a blister, 1 or 10 blisters in a carton box.

Storage

A dry, dark place, out of the reach of children, at a temperature of 5 ° C to 25 ° C.

Shelf life is 3 years. Half a tablet can be returned to the blister and used within 24 hours.

For use in veterinary medicine!