Quivitan 100ml

Quivitan
for the treatment of diseases of bacterial etiology in cattle and pigs

COMPOSITION AND FORM OF RELEASE
Quivitan as an active ingredient in 1 ml contains 25 mg of cefkin (equivalent to 29.64 mg of cefkinoma sulfate), as an auxiliary substance ethyl oleate – up to 1 ml.
In appearance, Kvivitan is an oily suspension from white to yellowish-white. During storage, the formation of a precipitate is possible, which disappears when shaken.
The drug is packaged in 100 and 250 ml glass bottles of appropriate capacity, hermetically sealed with gray fluoropolymer rubber stoppers, reinforced with aluminum lids, packed in individual cardboard boxes. Each unit of consumer packaging is supplied with instructions for use.
Dispensed without a veterinarian’s prescription.

PHARMACOLOGICAL PROPERTIES
Quivitan refers to antibacterial drugs of the cephalosporin group.
Cefkinoma sulfate, which is part of the drug – 4th generation cephalosporin, has a wide spectrum of antibacterial action against most gram-positive and gram-negative bacteria, including  Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Staphylococcus aureus, Streptocostridium spp., , Actinobacillus spp ,, Citrobacter spp., Klebsiella spp., Pasterella spp., Proteus spp., Salmonella spp., Serratia marcescens, Histophilus somni, Arcanobacterium pyogenes, Bacillus spp., Corynebacterium spp., Bacterium spp. Prevotella spp . and  Erysipelothrix rhusiopathiaeincluding strains producing beta-lactamase. The mechanism of the antibacterial action of cefkinoma is to suppress the functional activity of bacterial enzymes transpeptidases and carboxypeptidases involved in binding the main component of the cell wall of microorganisms – peptidoglycan, which leads to disruption of the osmotic balance and destruction of the bacterial cell. After parenteral administration of the drug, cefkin enters the systemic circulation, reaching a maximum serum concentration in cattle after 60-90 minutes, in pigs – after 15-60 minutes and remains at a therapeutic level for 24 hours. Cefkin binds to serum proteins by less than 5%, is relatively quickly excreted from the body (half-life in cattle is 2-2.5 hours,
According to the degree of impact on the body, Kvivitan belongs to low-hazard substances (hazard class 5 according to GOST 32644-2014), in recommended doses it does not have embryotoxic, teratogenic and carcinogenic effects.

INDICATIONS
Quivitan is used in cattle for the treatment of respiratory bacterial infections, interdigital dermatitis of bacterial etiology, necrobacteriosis and mastitis, including those caused by E. coli, Staphylococcus spp., Streptococcus spp., Escherichiosis (colibacillosis) of calves and other infections of sensitive bacterial etiology cefkinum by microorganisms. For pigs, the drug is prescribed for the treatment of respiratory bacterial infections, MMA syndrome (mastitis-metritis-agalactia), meningitis, arthritis, dermatitis and other infections of bacterial etiology caused by microorganisms sensitive to cefkin.

DOSES AND METHOD OF APPLICATION
Quivitan is administered to animals deeply intramuscularly once a day for 2-5 days, in doses indicated in the table.