Penstrep-400 Solution for Inj – 100 ml

Penstrep-400 Solution for Injection

Description:

Sterile white suspension for injection.

Compound:

1 ml of the preparation contains active ingredients:

Benzylpenicillin procaine 200,000 MO

Dihydrostreptomycin sulfate 200 mg

Excipients: methyl parahydroxybenzoate, propyl parahydroxybenzoate, procaine hydrochloride, sodium citrate, sodium phosphate, sodium formaldehyde sulfoxylate, sodium hydroxide, lecithin, simethicone, xanthan.

Pharmacological properties:

The combination of procaine benzylpenicillin and dihydrostreptomycin sulfate acts synergistically.

Benzylpenicillin procaine is a bactericidal antibiotic of the penicillin series that acts on gram-positive and gram-negative bacteria: Campylobacter spp., Clostridium spp., Corynebacterium spp., Erysipelothrix, Actinomyces spp., Hemophilus Stucco spp., Listeria spp.,. … The mechanism of its action is to disrupt the synthesis of peptidoglycan, a mucopeptide of the cell wall, which leads to inhibition of the synthesis of the cell wall of the microorganism, inhibition of the growth and reproduction of bacteria.

Dihydrostreptomycin is an aminoglycoside antibiotic that acts bactericidal on gram-negative and gram-positive microorganisms (Pasteurella spp., Salmonella spp., E. coli, Klebsiella spp., Staphylococcus spp. Leptospira spp., Francisella tularensis, Yersinia pestis). It is inactive against anaerobes. Violates protein synthesis in the ribosomes of bacteria, inactivating transpeptidase. The bactericidal activity of aminoglycosides is due to the ability to disrupt protein synthesis as a result of binding to the 30S subunit of the bacterial ribosome.

Application:

Treatment of cattle, sheep, goats and pigs suffering from arthritis and mastitis, as well as diseases of the digestive canal, respiratory system, genitourinary system, which are caused by microorganisms sensitive to benzylpenicillin and dihydrostreptomycin, namely: Campylobacter spp., Clostridium spp., Corynebacterium spp., E. Coli, Erysipelothrix spp., Haemophilus spp., Klebsiella spp., Listeria spp., Pasteurella spp., Salmonella spp., Staphylococcus spp. and Streptococcus spp.

Dosage:

Intramuscularly in a dose:

• cattle – 1.0 ml per 20 kg of animal weight for 3 days;
• calves, goats, sheep, pigs – 1.0 ml per 10 kg of animal weight for 3 days.

Shake the bottle thoroughly before use.

If the dose of the drug when administered exceeds 20 ml – for cattle, 10 ml – for pigs and 5 ml – for sheep and goats, then the injection volume is halved and injected into different places.

Contraindications:

Hypersensitivity to penicillins and dihydrostreptomycin. Do not use in rabbits, guinea pigs, hamsters and other small herbivores, as well as animals with impaired renal function.

Do not use concomitantly with tetracyclines, macrolides, chloramphenicol and lincosamides.

Caveats:

Slaughter of animals for meat and consumption of milk for human consumption is allowed, respectively, 21 and 3 days after the last use of the drug. The meat and milk received before the specified time is disposed of or fed to unproductive animals, depending on the conclusion of the veterinary doctor.

Release form:

Vials made of transparent glass are closed with a rubber stopper for an aluminum rim of 100 ml.

Storage:

A dry, dark place out of the reach of children at temperatures from + 15 ° C to + 25 ° C.

After the first selection from the bottle, the drug must be used within 14 days, provided that it is stored in a dark place at a temperature of + 2 ° C to + 8 ° C.

Expiration date : 2 years.