Galapan D – Cloprostenol, 20 ml
Release form, composition, and packaging
Solution for injection is colorless.
1 ml | |
D-cloprostenol (sodium salt form) | 75 mcg |
Excipients: citric acid, sodium hydroxide, chlorocresol, ethanol, water d / i.
Pharmacological (biological) properties and effects
D-cloprostenol is a functional analog of prostaglandin F2 α with specific luteolytic activity. Its use in the luteal phase of the sexual cycle causes regression of the corpus luteum and creates conditions for the onset of physiological processes associated with a decrease in the level of progesterone. One injection of d-cloprostenol from the 7th day of the cycle to natural luteolysis results in immediate resorption of the corpus luteum. The mechanism of action of d-cloprostenol in the control of ovulation is based on the induction of luteolysis and a decrease in the concentration of progesterone.
After i / m administration of 75 μg of d-cloprostenol to sows, the maximum concentration of d-cloprostenol in blood plasma (2 μg / l) is reached between 30 and 80 minutes after administration. After i / m administration of 150 μg of d-cloprostenol to cows, the maximum concentration of d-cloprostenol (approximately 1.4 μg / L) is reached 90 minutes after administration. D-cloprostenol and its metabolites are excreted in urine and faeces. Less than 0.75% of the administered dose is eliminated with milk during the day; residual amounts of d-cloprostenol in the tissues have not been established.
Indications for the use of the drug GALAPAN
For the regulation and treatment of reproductive function in cows and sows for:
– synchronization and induction of sexual heat in heifers and cows;
– synchronization of farrowing sows;
– treatment of cows and heifers with functional disorders of the ovaries (persistent corpus luteum, luteal cyst);
– treatment of endometritis and pyometra (as a means of combination therapy);
– termination of pregnancy with fetal pathology.
Application procedure
The drug is administered intramuscularly. Before using the drug, a gynecological examination of animals is performed. The drug is used only in farms that are safe in terms of epizootic conditions.
For synchronization and induction of sexual heat in heifers and cows, Galapan is administered in a dose of 2 ml (150 μg of d-cloprostenol) in any phase of the sexual cycle (in cows in the period 40-60 days after calving). Animals that have come to hunt are inseminated. Animals that did not come into the hunt on the 11th day after the first injection are injected with the drug again at the same dose.
If insemination is carried out without detection of heat, then the animals are inseminated 72 hours and 96 hours after the second injection. To obtain positive results, insemination should be carried out in the first hunt after Galapan application.
For the induction of farrowing in sows, the drug is administered once in a dose of 1 ml (75 μg d-cloprostenol) 3 days before the expected date of farrowing.
For the treatment of functional disorders of the ovaries (persistent corpus luteum, luteal cyst), the drug is administered in a dose of 2 ml (150 μg d-cloprostenol). Animals that have come to hunt are inseminated. Animals that have not come into the hunt are injected with Galapan again at the same dose 10 days after the first administration and inseminated 72 hours and 96 hours after the repeated administration of the drug.
For the treatment of postpartum or chronic endometritis in cows, the drug is administered in a dose of 2 ml (150 μg of d-cloprostenol) in combination with agents of etiotropic pathogenetic and symptomatic therapy.
If necessary, re-introduction of Galapan is carried out after 10-12 days.
To terminate pregnancy in fetal pathology, Galapan is administered in a dose of 2 ml (150 μg d-cloprostenol).
Side effects
There were no side effects and complications when using the drug in accordance with the instructions.
Contraindications to the use of the drug GALAPAN
– pregnant animals (with the exception of cases of termination of pregnancy in case of fetal pathology);
– with an abnormal position of the fetus;
– animals with cardiovascular or respiratory diseases.
Special instructions and measures for personal prevention
Slaughter of cows and sows for meat is allowed no earlier than 48 hours after the last injection of the drug. Meat of animals forcedly killed before the expiration of the specified period can be used for feeding carnivores.
Cow’s milk can be used for food purposes without restrictions.
Personal prevention measures
When working with Galapan, it is necessary to observe the general rules of personal hygiene and safety measures provided for when working with medicines.
Terms and conditions of storage
The drug should be stored in the manufacturer’s sealed packaging, separately from food and feed, in a dry place protected from direct sunlight, at a temperature not exceeding 25C °. Shelf life is 2 years.
Galapan should be kept out of the reach of children.