Cerenia, Solution for Injection for cats and dogs
Cerenia Solution for Injection is indicated for the following:
Dogs:
•For the prevention of vomiting except that induced by motion sickness.
•For the treatment of vomiting, in combination with other supportive measures.
•For the treatment and prevention of nausea induced by chemotherapy.
•For the prevention of perioperative nausea and vomiting and improvement in recovering from general anaesthesia after use of the µ-opiate receptor agonist morphine.
Cats:
•For the prevention of vomiting and the reduction of nausea, except that induced by motion sickness.
•For the treatment of vomiting, in combination with other supportive measures.
Composition and form of release
Cerenia contains in 1 ml:
maropitanta citrate – 10 mg,
Excipients:
metacresol – 3.3 mg,
sodium sulfobutyl ether-cyclodexitrine – 63 mg and water for injection – up to 1 ml.
In appearance, the drug is a clear, light yellow liquid.
The drug is packaged in 20 ml bottles made of dark glass, sealed with rubber stoppers, reinforced with aluminum caps.
Vials are packed in individual cardboard boxes.
Each box with the drug contains instructions for its use.
Pharmacological properties
Cerenia belongs to the group of antiemetics.
The active substance of Serenia – maropitant citrate – is an antagonist of neurokinin receptors (NK1) and inhibits the binding of substance P, a neutropeptide of the tachykinin group, in the central nervous system.
Maropitanta citrate is effective in vomiting of both central and peripheral genesis. Maropitant is rapidly absorbed from the injection site and reaches its maximum plasma concentration 45 minutes after administration.
More than 99% of maropitant binds to blood plasma proteins.
The bioavailability of Serenia is 90%.
Maropitant is metabolized in the liver by cytochrome P450, excreted mainly in feces.
According to the degree of effect on the body of maropitant, citrate is classified as a moderately hazardous substance.
Indications
It is prescribed for dogs and cats to prevent vomiting caused by movement of the animal (motion sickness syndrome), as well as in other pathologies accompanied by vomiting.
Doses and method of administration
Cerenia solution for injection is administered only subcutaneously at a dose of 1 mg of maropitant citrate per 1 kg of animal weight, which corresponds to 1 ml of the drug per 10 kg of animal weight, once a day for no more than 5 days.
Overdose symptoms have not been established.
No peculiarities of action at the beginning of administration and withdrawal of the drug were revealed.
Skips should be avoided with the introduction of the next dose of the drug, as this can lead to a decrease in effectiveness.
If one dose is missed, the course of treatment should be resumed in the dosages and dosage regimen prescribed by the instructions.
Side effects
When using Serenia in accordance with the instructions, side effects and complications, as a rule, are not noted.
Allergic reactions are possible in hypersensitive animals.
In some cases, salivation, lethargy, lack of appetite and diarrhea are noted.
In case of allergic reactions, the use of the drug is discontinued and antihistamines and symptomatic treatment are prescribed.
Contraindications
Increased individual sensitivity to the components of the drug. It is forbidden to use in pregnant and lactating animals.
Not recommended for puppies under 16 weeks of age.
special instructions
It is recommended to use Serenia after consulting a veterinarian.
Prescribe with caution to animals with liver diseases and a predisposition to diseases of the cardiovascular system.
There is no information on the interaction of Serenia with other medicinal products.
The medicinal product is not intended for use in productive animals.
Personal prevention measures
When working with Serenia, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines. After handling the preparation, wash your hands with soap and water.
In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they should be rinsed with plenty of water.
People with hypersensitivity to the components of Serenia should avoid direct contact with the drug.
In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (you should have instructions for using the drug or a label with you).
Empty vials from under the medicinal product must not be used for domestic purposes, they must be disposed of with household waste.
Storage conditions
In the sealed manufacturer’s packaging, in a dry, protected from the sun, out of the reach of children.
Separated from food and feed at temperatures from 3 ° C to 25 ° C.
The shelf life of the medicinal product, subject to storage conditions, is 36 months from the date of manufacture.
After taking part of the drug from the vial, subject to the rules of asepsis and the specified storage conditions, it can be used repeatedly, within 90 days.
It is forbidden to use the drug Serenia after the expiration date.
The unused medicinal product is disposed of in accordance with legal requirements.